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Researchers 3D Print Electronics and Cells Directly on Skin

Summary: Researchers have developed a new method of 3D printing that allows for electronics to be printed on the hand. The team also printed biological cells onto a skin wound of a mouse. They hope this new technique could lead to a new method for providing skin grafts and wound care.

Source: University of Minnesota.

In a groundbreaking new study, researchers at the University of Minnesota used a customized, low-cost 3D printer to print electronics on a real hand for the first time. The technology could be used by soldiers on the battlefield to print temporary sensors on their bodies to detect chemical or biological agents or solar cells to charge essential electronics.

Researchers also successfully printed biological cells on the skin wound of a mouse. The technique could lead to new medical treatments for wound healing and direct printing of grafts for skin disorders.

The research study was published today on the inside back cover of the academic journal Advanced Materials.

“We are excited about the potential of this new 3D-printing technology using a portable, lightweight printer costing less than $400,” said Michael McAlpine, the study’s lead author and the University of Minnesota Benjamin Mayhugh Associate Professor of Mechanical Engineering. “We imagine that a soldier could pull this printer out of a backpack and print a chemical sensor or other electronics they need, directly on the skin. It would be like a ‘Swiss Army knife’ of the future with everything they need all in one portable 3D printing tool.”

One of the key innovations of the new 3D-printing technique is that this printer can adjust to small movements of the body during printing. Temporary markers are placed on the skin and the skin is scanned. The printer uses computer vision to adjust to movements in real-time.

3d printed electronics

One of the key innovations of the new 3D-printing technique on skin is that the printer uses computer vision to track and adjust to movements in real-time. NeuroscienceNews.com image is credited to McAlpine group, University of Minnesota.

“No matter how hard anyone would try to stay still when using the printer on the skin, a person moves slightly and every hand is different,” McAlpine said. “This printer can track the hand using the markers and adjust in real-time to the movements and contours of the hand, so printing of the electronics keeps its circuit shape.”

Another unique feature of this 3D-printing technique is that it uses a specialized ink made of silver flakes that can cure and conduct at room temperature. This is different from other 3D-printing inks that need to cure at high temperatures (up to 100 degrees Celsius or 212 degrees Fahrenheit) and would burn the hand.

To remove the electronics, the person can simply peel off the electronic device with tweezers or wash it off with water.

In addition to electronics, the new 3D-printing technique paves the way for many other applications, including printing cells to help those with skin diseases. McAlpine’s team partnered with University of Minnesota Department of Pediatrics doctor and medical school Dean Jakub Tolar, a world-renowned expert on treating rare skin disease. The team successfully used a bioink to print cells on a mouse skin wound, which could lead to advanced medical treatments for those with skin diseases.

“I’m fascinated by the idea of printing electronics or cells directly on the skin,” McAlpine said. “It is such a simple idea and has unlimited potential for important applications in the future.”

In addition to McAlpine and Tolar, the University of Minnesota team includes Ph.D. students Zhijie Zhu and Xiaoxiao Fan and postdoctoral researcher Shuang-Zhuang Guo from the Department of Mechanical Engineering in the College of Science and Engineering; and research staff Cindy Eide and Tessa Hirdler from the Department of Pediatrics in the Medical School.

This study was funded by grants from the National Institutes of Health and state-funded Regenerative Medicine Minnesota. In addition, the first author of the paper Zhijie Zhu was funded by a University of Minnesota Interdisciplinary Doctoral Fellowship.

About this neuroscience research article

Source: University of Minnesota
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is image is credited to McAlpine group, University of Minnesota.
Video Source: Videos are credited to College of Science and Engineering, UMN.
Original Research: Abstract for “3D Printed Functional and Biological Materials on Moving Freeform Surfaces” by Zhijie Zhu, Shuang‐Zhuang Guo, Tessa Hirdler, Cindy Eide, Xiaoxiao Fan, Jakub Tolar, and Michael C. McAlpine in Advanced Materials. Published April 25 2018.
doi:10.1002/adma.201707495

Cite This NeuroscienceNews.com Article
University of Minnesota “Researchers 3D Print Electronics and Cells Directly on Skin.” NeuroscienceNews. NeuroscienceNews, 26 April 2018.
<http://neurosciencenews.com/3d-print-cells-skin-8891/>.
University of Minnesota (2018, April 26). Researchers 3D Print Electronics and Cells Directly on Skin. NeuroscienceNews. Retrieved April 26, 2018 from http://neurosciencenews.com/3d-print-cells-skin-8891/
University of Minnesota “Researchers 3D Print Electronics and Cells Directly on Skin.” http://neurosciencenews.com/3d-print-cells-skin-8891/ (accessed April 26, 2018).

Abstract

3D Printed Functional and Biological Materials on Moving Freeform Surfaces

Conventional 3D printing technologies typically rely on open‐loop, calibrate‐then‐print operation procedures. An alternative approach is adaptive 3D printing, which is a closed‐loop method that combines real‐time feedback control and direct ink writing of functional materials in order to fabricate devices on moving freeform surfaces. Here, it is demonstrated that the changes of states in the 3D printing workspace in terms of the geometries and motions of target surfaces can be perceived by an integrated robotic system aided by computer vision. A hybrid fabrication procedure combining 3D printing of electrical connects with automatic pick‐and‐placing of surface‐mounted electronic components yields functional electronic devices on a free‐moving human hand. Using this same approach, cell‐laden hydrogels are also printed on live mice, creating a model for future studies of wound‐healing diseases. This adaptive 3D printing method may lead to new forms of smart manufacturing technologies for directly printed wearable devices on the body and for advanced medical treatments.

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