Genetically engineered mice with a human gene for schizophrenia and who were exposed to lead early in life, exhibited behavioral and structural changes in the brain consistent with schizophrenia. Researchers believe their findings show a synergistic effect between lead exposure and the schizophrenia gene.
A new study funded by the NIMH suggests GLYX-13, a molecular cousin to ketamine, induces similar antidepressant results without the negative side effects of the well known street drug.
When elevated levels of neuregulin-1, a gene associated with schizophrenia, are returned to normal, the symptoms of the illness disappear.
A new study reveals neural circuitry is hyperactivated by performing certain tasks for children with a family history of schizophrenia, compare to peers without this family history. As the differences in brain function appear prior to the onset of psychiatric symptoms, researchers believe the findings could point to vulnerability markers for schizophrenia.
A new study which looked at eye movement in patients with Schizophrenia provides evidence of difficulties in reading fluency. The findings could help to provide early identification of the mental illness for some individuals.
Genes linked to autism and schizophrenia are only switched on during the early stages of brain development, according to a study in mice led by researchers at the University of Oxford.
Researchers show that the iDichotic smartphone app can be successfully used for psychological testing. A new version of this app has been specially developed for schizophrenic patients suffering from auditory hallucinations.
Researchers have identified an exceptional mouse model of schizophrenia. The study identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia.
Researchers discover four spectral features in the brain signals of schizophrenia patients that changed with age compared to healthy control subjects, suggesting that schizophrenia affects the way in which brain activity evolves with age.
A new study expands and deepens the biological and genetic links between cardiovascular disease and schizophrenia. Cardiovascular disease (CVD) is the leading cause of premature death among schizophrenia patients, who die from heart and blood vessel disorders at a rate double that of persons without the mental disorder.
Future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia, should greatly benefit from a first-of-its-kind atlas of gene-enhancers in the cerebrum (telencephalon). This new atlas identifies and locates thousands of gene-regulating elements in a region of the brain that is of critical importance for cognition, motor functions and emotion.
New research discovers an early step in how the brain's inhibitory cells get excited. Erbin, a protein critical to brain development, is also crucial for the excitement of inhibitory cells.