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psilocybin

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·March 18, 2026·9 min read

Psychedelics Match, But Don’t Beat, Traditional Antidepressants

New research reveals that the perceived advantage of psychedelics over antidepressants disappears when the "knowledge of treatment" factor is equalized.

This shows a head surrounded by mushrooms.

Featured Neuroscience Psychology

·March 6, 2026·6 min read

Healing Without the Hallucinations: The Next Generation of Psilocybin Therapy

Scientists have synthesized a new compound that delivers the benefits of magic mushrooms without the mind-altering side effects.

Featured Neuroscience Psychology

·March 4, 2026·8 min read

Psychedelics Remodel Myelin to Heal PTSD

New research reveals that psychedelics don't just rewire the brain—they physically repair the "neural insulation" needed to sustain long-term PTSD recovery.

Featured Neurology Neuroscience Pain Psychology

·October 2, 2025·6 min read

Psilocybin Rewire Brain Circuits Tied to Pain and Mood

New research shows that psilocybin, the active compound in psychedelic mushrooms, can reduce both chronic pain and pain-related depression by modulating brain circuits rather than acting at the site of injury. In mouse studies, a single dose provided pain relief and mood benefits lasting nearly two weeks by targeting the anterior cingulate cortex.

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Featured Neuroscience Psychology

·September 30, 2025·7 min read

Psilocybin Worsens Postpartum Depression Symptoms

New research shows psilocybin, often studied as a treatment for mental health disorders, may worsen symptoms of postpartum depression in mice. Mothers given the drug showed more anxiety, avoidance of their pups, and lasting depressive-like behaviors.

Featured Neuroscience Psychology

·July 19, 2025·6 min read

More Than Serotonin: How Psychedelics Engage the Whole Brain

Classical psychedelics like LSD, psilocybin, and mescaline are known for activating the 5-HT2A serotonin receptor, but a new study reveals their effects go far beyond. Researchers profiled 41 psychedelics against over 300 human receptors and found potent activity at serotonin, dopamine, and adrenergic sites.

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Featured Neuroscience

·July 9, 2025·4 min read

Psilocybin Shows Promise as Anti-Aging Therapy

Psilocybin, the active compound derived from psychedelic mushrooms, significantly delayed cellular aging and extended lifespan in a preclinical study. Researchers observed a 50% increase in the lifespan of human skin and lung cells and a 30% increase in survival in aged mice treated with psilocybin.

Featured Neuroscience Psychology

·June 10, 2025·4 min read

Psilocybin Elevates Spiritual Awareness

Psilocybin significantly enhances psychological well-being and spiritual insight among clergy members across major world religions. Participants reported lasting positive changes in religious practice, personal beliefs, and vocational effectiveness after two guided psilocybin sessions.

This shows a person sitting and mushrooms.

Featured Neurology Neuroscience

·April 30, 2025·6 min read

Psilocybin Shows Promise for Parkinson’s Mood and Motor Symptoms

A new pilot study reveals that psilocybin—the compound found in psychedelic mushrooms—may significantly improve mood, cognition, and motor function in people with Parkinson’s disease. The compound was well tolerated, with only mild side effects, and benefits persisted for weeks after dosing. While the study was primarily designed to test safety, researchers observed meaningful and lasting improvements in multiple symptoms.

Featured Neuroscience Psychology

·April 22, 2025·4 min read

More People Turning to Psilocybin for Self-Treatment

Psilocybin use in the U.S. has risen sharply across all age groups since 2019, coinciding with increasing legalization and interest in its therapeutic potential. A new study reveals a 44% rise in past-year use among young adults and a 188% increase among those over 30.

Featured Neuroscience Psychology

·April 4, 2025·3 min read

How Psilocybin Lifts Mood Without the Hallucinogenic Trip

Researchers have uncovered two key brain mechanisms—specific neurons and a serotonin receptor—that help explain how psilocybin produces long-lasting antidepressant effects. Their study identified pyramidal tract neurons in the medial frontal cortex and the serotonin 5-HT2A receptor as essential to the therapeutic action of psilocybin.

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Featured Neuroscience Psychology

·October 8, 2024·3 min read

Optimism Boosted by Psilocybin, Hinting at Depression Relief

Researchers have discovered that psilocybin, a psychedelic compound in magic mushrooms, increases optimism and motivation in rats, suggesting potential therapeutic benefits for treating depression. Using computational modeling, scientists observed that rats given psilocybin were more likely to engage in reward-based tasks, indicating enhanced optimism.