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psilocybin

·May 15, 2026·10 min read

Single Psilocybin Dose Sparks Rapid Depression Remission

Can a single dose of psilocybin replace daily antidepressants? A new randomized clinical trial shows that a 25 mg dose of the psychedelic compound delivers rapid, clinically meaningful symptom reductions for common depression in just 48 hours.

Featured Neuroscience Psychology

·May 7, 2026·9 min read

Psilocybin Rebuilds the Brain’s Physical Wiring

New research from UCSF shows that a single high dose of the psychedelic compound creates lasting anatomical changes in brain tracts and "loosens" rigid thought patterns, leading to significant improvements in psychological insight and well-being that persist for over a month.

This shows a person's head and mushrooms.

Featured Neuroscience Open Neuroscience Articles Psychology

·May 7, 2026·8 min read

Psilocybin Dampens Aggression and Attack Behaviors

New research shows that low doses of the psychoactive compound can reduce high-energy aggressive behaviors in mangrove rivulus fish while keeping social communication intact, offering a new vertebrate model for studying the drug's impact on social conflict.

This shows an illustration of colorful, psychedelic neurons.

Featured Neuroscience Psychology

·April 8, 2026·8 min read

How Science Solved the Mystery of the Psychedelic High

A massive international study identifies a universal pattern of brain activity across psilocybin, LSD, DMT, and more. Researchers found that all major psychedelics dissolve brain network boundaries, triggering global "cross-talk."

This shows a scale, a pill and mushrooms.

Featured Neuroscience Psychology

·March 18, 2026·9 min read

Psychedelics Match, But Don’t Beat, Traditional Antidepressants

New research reveals that the perceived advantage of psychedelics over antidepressants disappears when the "knowledge of treatment" factor is equalized.

This shows a head surrounded by mushrooms.

Featured Neuroscience Psychology

·March 6, 2026·6 min read

Healing Without the Hallucinations: The Next Generation of Psilocybin Therapy

Scientists have synthesized a new compound that delivers the benefits of magic mushrooms without the mind-altering side effects.

Featured Neuroscience Psychology

·March 4, 2026·8 min read

Psychedelics Remodel Myelin to Heal PTSD

New research reveals that psychedelics don't just rewire the brain—they physically repair the "neural insulation" needed to sustain long-term PTSD recovery.

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·October 2, 2025·6 min read

Psilocybin Rewire Brain Circuits Tied to Pain and Mood

New research shows that psilocybin, the active compound in psychedelic mushrooms, can reduce both chronic pain and pain-related depression by modulating brain circuits rather than acting at the site of injury. In mouse studies, a single dose provided pain relief and mood benefits lasting nearly two weeks by targeting the anterior cingulate cortex.

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Featured Neuroscience Psychology

·September 30, 2025·7 min read

Psilocybin Worsens Postpartum Depression Symptoms

New research shows psilocybin, often studied as a treatment for mental health disorders, may worsen symptoms of postpartum depression in mice. Mothers given the drug showed more anxiety, avoidance of their pups, and lasting depressive-like behaviors.

Featured Neuroscience Psychology

·July 19, 2025·6 min read

More Than Serotonin: How Psychedelics Engage the Whole Brain

Classical psychedelics like LSD, psilocybin, and mescaline are known for activating the 5-HT2A serotonin receptor, but a new study reveals their effects go far beyond. Researchers profiled 41 psychedelics against over 300 human receptors and found potent activity at serotonin, dopamine, and adrenergic sites.

This shows a psychedelic brain and mushrooms.

Featured Neuroscience

·July 9, 2025·4 min read

Psilocybin Shows Promise as Anti-Aging Therapy

Psilocybin, the active compound derived from psychedelic mushrooms, significantly delayed cellular aging and extended lifespan in a preclinical study. Researchers observed a 50% increase in the lifespan of human skin and lung cells and a 30% increase in survival in aged mice treated with psilocybin.

Featured Neuroscience Psychology

·June 10, 2025·4 min read

Psilocybin Elevates Spiritual Awareness

Psilocybin significantly enhances psychological well-being and spiritual insight among clergy members across major world religions. Participants reported lasting positive changes in religious practice, personal beliefs, and vocational effectiveness after two guided psilocybin sessions.