Using cryoEM technology, researchers have decoded the detailed structures of an entire family of opioid receptors bound to their naturally occurring peptides. This new structural framework should help in the development of safer, more effective medications to treat chronic pain.
Shorter daylight hours increase opioid receptor signaling in the brown fat of animals.
The seasonal duration of daylight influences the number of opioid receptors in the brain. The findings shed new light on a potential mechanism behind seasonal affective disorder.
Age, sex, and gender influence the organization of the brain's opioid system. Findings shed light on why there are significant differences between the opioid system on an individual level, and why some are more prone to developing opioid-linked pathologies than others.
A new study clarifies the mechanism behind how ketamine works as an antidepressant. Researchers say there is evidence to suggest ketamine binds to NMDA receptors, instead of opioid receptors. Reducing the belief that ketamine is an opioid may make patients with depression more open to using the treatment.
Researchers have successfully activated the brain's opioid receptors using optogenetics.
Using neuroimaging technology, researchers discover lower numbers of opioid receptors in the brain of obese people.
Researchers have identified a subset of neurons which mediate tactile allodynia, a touch evoked pain condition that is resistant to conventional pain medications.
Researchers describe a pair of drug candidates which advance the search for new treatments for addiction, pain and other disorders.
Researchers discover how sodium influences the signalling of opioid receptors.
Researchers have developed a variant of the Mu opioid receptor which has several advantages for experimentation The variant can be grown in large quantities and is water soluble, allowing for experiments and applications which have previously been challenging.