Researchers found a positive correlation between glioblastoma cell proliferation and lactate metabolic indicators. Based on this observation, the researchers developed a biomimetic formulation using targeted delivery agents for lactate metabolism-based synergistic therapy against glioblastoma brain cancer.
In mice, protein lactylation occurs in neurons and is correlated with lactate levels. Protein lactylation is enhanced by neural excitation and social stress. Researchers found social stress specifically enhances lysine lactylation of histone H1 proteins.
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Axon regeneration and dramatic improvements in functional recovery occurred when lactate was applied to damaged neural tissue. Treatment with lactate also significantly improved locomotion and restored some walking capability in mouse models of SCI.
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Researchers discover imbalanced pH and lactate levels in the brains of mouse models of schizophrenia, ASD and bipolar disorder. They believe the imbalances could reflect an underlying pathophysiology to some psychiatric disorders.
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Researchers have discovered how lactate can protect neurons from damage following acute trauma.
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Lactate causes neurons to release more norepinephrine, a new study reports.