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lactate

·July 24, 2023·4 min read

Neuronal Boost: Lactate’s Key Role in Brain Development Uncovered

Researchers discovered the critical role lactate plays in the development of neural stem cells into specialized neurons. They found that lactate sends signals to these cells, aiding in the modification and strengthening of neuronal functions.

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·July 22, 2022·4 min read

New Biomimetic Formulation for Treating Glioblastoma

Researchers found a positive correlation between glioblastoma cell proliferation and lactate metabolic indicators. Based on this observation, the researchers developed a biomimetic formulation using targeted delivery agents for lactate metabolism-based synergistic therapy against glioblastoma brain cancer.

Featured Neuroscience Open Neuroscience Articles Psychology

·October 12, 2021·3 min read

Protein Lactylation Is Induced in the Brain by Neural Activation and Social Stress

In mice, protein lactylation occurs in neurons and is correlated with lactate levels. Protein lactylation is enhanced by neural excitation and social stress. Researchers found social stress specifically enhances lysine lactylation of histone H1 proteins.

Featured Neurology Neuroscience

·September 16, 2020·5 min read

New Path to Neuron Regeneration After Spinal Cord Injury Discovered

Axon regeneration and dramatic improvements in functional recovery occurred when lactate was applied to damaged neural tissue. Treatment with lactate also significantly improved locomotion and restored some walking capability in mouse models of SCI.

Featured Neuroscience Psychology

·August 7, 2017·5 min read

Brain Acidity Imbalance in Psychiatric Disorders

Researchers discover imbalanced pH and lactate levels in the brains of mouse models of schizophrenia, ASD and bipolar disorder. They believe the imbalances could reflect an underlying pathophysiology to some psychiatric disorders.