Flies without the Rim gene or cac Cav2 channel function displayed numerous cognitive and behavioral deficits associated with schizophrenia, and had reductions in synaptic growth and neural calcium transients. Exposing the flies with Rim deficits to the common antipsychotic haloperidol reduced some of the schizophrenia-related behavioral symptoms.
A link has been identified between psychosis and a genetic change that alters the immune system in the brain. Researchers found people with psychosis associated with bipolar disorder had decreased expression of GRK3. This led to an increased amount of kynurenic acid in the brain.
While England has only seen a moderate rise in people being diagnosed with psychosis in recent years, prescription rates for antipsychotic medications have doubled.
Study reveals the function of a specific protein works differently in the brains of men and women. The findings help explain why some psychiatric disorders and resistance to treatments vary between the sexes.
Study reveals a link between people with depression who are prescribed newer antipsychotic medications and higher mortality risk.
Typical interventions for schizophrenia do not improve long-term outcomes, even when administered early, a new study reports.
During memory tasks, people with psychosis have different patterns of activity in the prefrontal and mediotemporal brain areas compared to those without the disorder. When exposed to cannabidiol (CBD), the activity of the brain areas became more like those seen in the controls for people with psychosis. Patients reported a decrease in symptoms of psychosis following one dose of CBD. Researchers stress that no definitive conclusions could be made about the effectiveness of CBD use over a sustained period.
Alzheimer's patients who used antipsychotics had a 29% increased risk of head injury and a 22% higher risk of TBI compared to others with the neurodegenerative disease who did not use the medications.
People with Alzheimer's disease who use antipsychotic medications have a 29% higher risk of head injury, and a 22% increased risk of TBI compared to those with the neurodegenerative disease who do not use the medications.