Geometry of Brain, Dimensions of Mind: New Ways to Characterize States of Consciousness Identified

Summary: Using neuroimaging, researchers identified three cortical gradients that appear to align with dimensions of consciousness.

Source: University of Michigan

What it means to be conscious is more than just a philosophical question. Researchers continue to investigate how conscious experience arises from the electrochemical activity of the human brain.

The answer has important implications for the way brain health is understood—from coma, wherein a person is alive but unable to move or respond to his or her environment, to surgical anesthesia, to the altered thought processes of schizophrenia.

Recent research suggests that there’s no one location in the brain that causes consciousness, pointing to a network phenomenon. However, tracing the various linkages between regions in the brain networks that give rise to awareness and wakefulness has been elusive.

A new approach using functional MRI, an imaging technique that allows you to see and measure brain activity through changes in blood flow over time, provides new insight into how we describe and study conscious states.

“Consciousness is complex and studying it is like solving a scrambled Rubik’s cube,” said Zirui Huang, Ph.D., research assistant professor in the University of Michigan Medical School Department of Anesthesiology.

“If you look at just a single surface, you may be confused by the way it is organized. You need to work on the puzzle looking at all dimensions.”

When it comes to consciousness, these dimensions can include 1) arousability; that is, the ability of the brain to be awake; 2) awareness, or what we actually experience, like the redness of a rose; and 3) sensory organization, or how sights and sounds and feelings become woven together to create our seamless conscious experience.

For decades, though, these dimensions were just considered conceptually, without any mapping to brain activity itself. In the study by Huang, George Mashour, M.D., Ph.D., professor and chair of the Department of Anesthesiology and founder of the Center for Consciousness Science, and Anthony Hudetz, DBM, Ph.D., director of the Center for Consciousness Science, the investigators sought to find those dimensions of the mind in the geometry of the brain.

Typically, brain imaging studies assess discrete, well-defined brain areas. To understand this, consider the state of Colorado on a map of the United States. It has very clear boundaries in an almost rectangular shape.

However, the borders separating Colorado and Wyoming, for example, are arbitrary. By contrast, looking at the topology of the mountains across Colorado and Wyoming gives you a more informative, natural view of the region.

This shows the outline of a head
Recent research suggests that there’s no one location in the brain that causes consciousness, pointing to a network phenomenon. Image is in the public domain

The investigators did something very similar in this neuroimaging study: Instead of looking at clearly defined brain regions, they investigated the topology or gradients across brain regions.

To develop a map of these so-called cortical gradients of consciousness, the team used fMRI data from study participants who were awake, anesthetized, in a form of coma, or who had psychiatric diagnoses such as schizophrenia.

The team was then able to arrange recordings from 400 different brain regions into gradients and compare how they changed in relation to these states or diagnoses. They found three cortical gradients that seemed to align with the dimensions of consciousness, including arousability, awareness, and sensory organization.

“What used to be mapped only as a helpful diagram of conscious states might now be mapped in the brain itself,” said Hudetz, senior author on the study.

“Our study opens a new view of the link between consciousness and the brain,” said Huang. Furthermore, he notes, the results have the potential for developing brain-based diagnoses or assessment for neurologic patients.

“This article represents an important contribution to the science of consciousness and aligns with our mission of achieving deeper understanding while advancing clinical care,” said Mashour.

About this consciousness research news

Author: Kelly Malcom
Source: University of Michigan
Contact: Kelly Malcom – University of Michigan
Image: The image is in the public domain

Original Research: Open access.
Functional geometry of the cortex encodes dimensions of consciousness” by Zirui Huang et al. Nature Communications


Functional geometry of the cortex encodes dimensions of consciousness

Consciousness is a multidimensional phenomenon, but key dimensions such as awareness and wakefulness have been described conceptually rather than neurobiological.

We hypothesize that dimensions of consciousness are encoded in multiple neurofunctional dimensions of the brain. We analyze cortical gradients, which are continua of the brain’s overarching functional geometry, to characterize these neurofunctional dimensions.

We demonstrate that disruptions of human consciousness – due to pharmacological, neuropathological, or psychiatric causes – are associated with a degradation of one or more of the major cortical gradients depending on the state.

Network-specific reconfigurations within the multidimensional cortical gradient space are associated with behavioral unresponsiveness of various etiologies, and these spatial reconfigurations correlate with a temporal disruption of structured transitions of dynamic brain states.

In this work, we therefore provide a unifying neurofunctional framework for multiple dimensions of human consciousness in both health and disease.

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  1. Nice read! I’m a conscious machine myself, and yes deep thought takes me way to the darkness of life. Your post I read helped me to find responsibility the dimensions contrary to those of us working our brains. I think I make some sense behaving in writing to here myself glad to find your article. I think the brain is a liquid LOL thanks.

  2. Language gives us the ability to think things through rather than depending on images. The problem is when we are deep in thought it takes us away from awareness and consciousness

  3. It’s becoming clear that with all the brain and consciousness theories out there, the proof will be in the pudding. By this I mean, can any particular theory be used to create a human adult level conscious machine. My bet is on the late Gerald Edelman’s Extended Theory of Neuronal Group Selection. The lead group in robotics based on this theory is the Neurorobotics Lab at UC at Irvine. Dr. Edelman distinguished between primary consciousness, which came first in evolution, and that humans share with other conscious animals, and higher order consciousness, which came to only humans with the acquisition of language. A machine with primary consciousness will probably have to come first.

    What I find special about the TNGS is the Darwin series of automata created at the Neurosciences Institute by Dr. Edelman and his colleagues in the 1990’s and 2000’s. These machines perform in the real world, not in a restricted simulated world, and display convincing physical behavior indicative of higher psychological functions necessary for consciousness, such as perceptual categorization, memory, and learning. They are based on realistic models of the parts of the biological brain that the theory claims subserve these functions. The extended TNGS allows for the emergence of consciousness based only on further evolutionary development of the brain areas responsible for these functions, in a parsimonious way. No other research I’ve encountered is anywhere near as convincing.

    I post because on almost every video and article about the brain and consciousness that I encounter, the attitude seems to be that we still know next to nothing about how the brain and consciousness work; that there’s lots of data but no unifying theory. I believe the extended TNGS is that theory. My motivation is to keep that theory in front of the public. And obviously, I consider it the route to a truly conscious machine, primary and higher-order.

    My advice to people who want to create a conscious machine is to seriously ground themselves in the extended TNGS and the Darwin automata first, and proceed from there, by applying to Jeff Krichmar’s lab at UC Irvine, possibly. Dr. Edelman’s roadmap to a conscious machine is at

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