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·June 24, 2020

One-time treatment generates new neurons and eliminates Parkinson’s disease

Researchers administered PTB antisense oligonucleotide treatment directly to the midbrain of mice. In the mouse models exposed to the treatment, a small subset of astrocytes converted to neurons, increasing the number of neurons by 30%. Three months after treatment, mice were completely free of Parkinson's disease symptoms and remained in remission for the rest of their lives. Read More

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·May 20, 2020

Link between diesel exhaust and risk of Parkinson’s discovered

Researchers have uncovered the process by which air pollution can damage brain cells, leading to an increased risk of Parkinson's disease. Chemicals found in diesel fuel reduced autophagic flux, which is a major pathway implicated in neurodegeneration. Read More

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·May 1, 2020

Parkinson’s dyskinesia mechanism explained

Involuntary movements and tremors caused as a result of taking dopamine replacement medications for Parkinson's disease can be alleviated through the suppression of RasGRP1. Read More

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·April 27, 2020

More evidence Parkinson’s disease may start in the gut

Enteric neurons appear to play a key role in the development of Parkinson's disease. The findings support the hypothesis and previous studies that the neurodegenerative disease may start in the gut before spreading to the brain. Researchers also found oligodendrocytes were affected during the early stages of Parkinson's, even before the loss of dopaminergic neurons. Read More

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·March 13, 2020

‘Natural killer’ cells could halt Parkinson’s progression

Natural killer cells may play a critical role in regulating and restraining neuroinflammation and protein clumping associated with Parkinson's disease. Read More

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·February 23, 2020

Iron in brain shows cognitive decline in people with Parkinson’s

The measure of iron in the brain may help doctors predict which patients with Parkinson's disease are most likely to develop dementia. Read More

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·June 15, 2020

Disrupted circadian rhythms linked to later Parkinson’s diagnoses

Circadian rhythm disruptions in older men have been linked to an increased risk of developing Parkinson's disease. The findings suggest circadian disruptions may reflect the neurodegenerative processes already affecting the brain's internal clock prior to the diagnosis of Parkinson's. Circadian disruptions, researchers say, could be considered an early warning sign of Parkinson's. Read More

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·May 5, 2020

New evidence that higher caffeine and urate levels are protective against Parkinson’s

Caffeine and urate have been associated with a reduced risk of idiopathic Parkinson's disease. Researchers noted a lower caffeine intake in idiopathic Parkinson's patients. Increasing caffeine consumption was linked to decreased odds of being diagnosed with Parkinson's. Lower levels of blood urate were also associated with an increased risk of Parkinson's disease. Read More

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·April 27, 2020

Light-based deep brain stimulation relieves symptoms of Parkinson’s disease

Researchers use optogenetic based deep brain stimulation to help treat motor dysfunction in animal models of Parkinson's disease. The new technique provides insights into why DBS works and ways in which it can be improved on a patient-by-patient basis. Read More

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·April 20, 2020

Further evidence autoimmunity plays a role in Parkinson’s disease

T cells that react to alpha-synuclein are most abundant in the early stages of Parkinson's disease but tend to disappear as the disease progresses. Signs of autoimmunity can appear in Parkinson's patients up to ten years before a diagnosis of the neurodegenerative disease. The detection of T cell response could be an early biomarker for Parkinson's, long before the physical symptoms begin to manifest. Read More

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·March 11, 2020

New target for Parkinson’s therapies identified

Two regions outside of the non-amyloid-beta-component play a critical role in controlling amyloid formation of alpha-synuclein. Read More

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·February 18, 2020

Parkinson’s biomarker may originate in gut

Using mouse models, researchers seeded alpha-synuclein aggregates in gut neurons and discovered the clumps can travel to neurons in the brain. Read More