Alterations in the nascent transcription of introns may indicate risk factors for, and the progression of Parkinson's disease.
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The Parkinson's-associated protein alpha-synuclein appears to act as a "toggle switch" that helps control vesicle transportation and gene expression. In a diseased state, this delicate balance is broken. The findings have implications for the development of new treatments for Parkinson's disease.
Neurons in the parafascicular thalamus project to three different parts of the basal ganglia. Targeting these circuits could be a new target for treating motor dysfunction and depression associated with Parkinson's disease.
Researchers have developed a new biomarker that will enable a rapid and inexpensive test for Parkinson's disease.
A new computer model shows the beneficial effects of deep brain stimulation arise from how it interrupts the cycle promoting runway beta in a circuit loop between the subthalamic nucleus and striatum.
Researchers have designed a new method of converting non-neural cells into functioning neurons that are able to form synapses, dispense dopamine, and restore the function of neurons undermined by Parkinson's associated destruction of dopaminergic cells.
Researchers identified LIPE, a lipase that degrades triglycerides to produce fatty acids, as a potential new target for the development of treatments for Parkinson's disease.
Older adults who frequently experience bad dreams or nightmares are twice as likely to be diagnosed with Parkinson's disease, a new study reports.
A newly invented soft, implantable probe can interface between gut and brain tissue, measuring both dopamine and serotonin levels. The device has applications for depression, Parkinson's disease, and intestinal disorders.
Volume decreases in cortical areas, the amygdala, and basal forebrain in Parkinson's patients correlated with worsening symptoms of the disease.
Study implicates the gene DJ1 in neuronal death associated with Parkinson's disease.
A specific Parkinson's related gene could be a driver behind vocal production problems associated with the disease. The findings could lead to earlier diagnosis and treatment of Parkinson's disease.
