Transplanted brain stem cells survive without anti-rejection drugs
Researchers have developed a new method to transplant neural stem cells into mice without the need for lifelong anti-rejection medications.... Read More...
stem cells
Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells
APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.... Read More...
Scientists identify gene as master regulator in schizophrenia
TCF4 may serve as a master regulator of a gene network dysregulated in schizophrenia at the early stages of neurodevelopment.... Read More...
Creation of new brain cells plays an underappreciated role in Alzheimer’s disease
Microglia may play a significant role in disrupting neurogenesis in those with Alzheimer's disease. When mice were given drugs which caused microglial cells to die, neurogenesis returned to normal.... Read More...
Human developmental clock mimicked in a dish
The human development 'clock in a dish' opens up new avenues for research and provides a way to replicate developmental disorders.... Read More...
Signal blocks stem cell division in the geriatric brain
A gene regulated called Id4 appears to be a key component in controlling stem cell proliferation. ... Read More...
Researchers take aim at circadian clock in deadly brain cancer
Glioblastoma stem cells' circadian clocks ramp up the cells' metabolism, making them stronger, more resistant to treatment, and able to divide and multiply more rapidly. By targeting the stem cells with a small molecule drug, researchers found mice models lived longer and their tumors shrank.... Read More...
Scientists reverse aging process in rat brain stem cells
Removing Piezo1 from the surface of aged brain stem cells caused the cells to become rejuvenated and regain their normal regenerative function.... Read More...
Adding MS drug to targeted cancer therapy may improve glioblastoma outcomes
Teriflunomide, a drug commonly used to treat multiple sclerosis, shows promise for the treatment of glioblastoma when coupled with targeted cancer therapies.... Read More...
To become, or not to become… a neuron
Bcl6 acts as a driver of neurogenic transition by directly silencing a selection of genes that belong to multiple extrinsic pathways promoting self-renewal. Bcl6 is only expressed in specific subsets of neurons and progenitor cells during brain development.... Read More...
Study looks at stem cells for answers to how a type of autism develops
Stem cell study reveals a genetic defect associated with fragile X syndrome delays the production of neurons during a critical stage of embryonic development. ... Read More...
Discovery of the cell fate switch from neurons to astrocytes in the developing brain
The FGF signaling pathway is an important extracellular regulator in the fate of neural stem cells switching from neurons to astrocytes in the cerebral cortex. ... Read More...