Female rats that experienced early life adversity developed abnormal connections between the amygdala and prefrontal cortex in response to neglect. Read More
Exposure to violence and childhood adversity has a negative effect on the developing brain. Neuroimaging reveals adolescents who experienced adversity and violence as children had reduced connectivity between the amygdala and the prefrontal cortex. However, social support may act as a buffer and reduce the negative effects of early life stress. Read More
The medial prefrontal cortex persistently encodes value based decision variables. Read More
A pathway linking the basal ganglia to the thalamus enhances sensory discrimination and is used to suppress 'background noise'. The pathway, which is controlled by the prefrontal cortex, selectively suppresses sensory input as it flows to the thalamus. Read More
Researchers evaluate the psychological and neurobiological impact of teen cannabis use. The findings, to be presented at the 13th Annual Canadian Neuroscience Meeting, will cover how cannabis contributes to cognitive impairments, psychosis and deficits in decision making in adolescents. Read More
A cluster of epigenetic marks in an enhancer at IGF2 could enhance dopamine synthesis associated with psychosis in schizophrenia and bipolar disorder. The findings may help in devising more effective treatments and screening strategies for both disorders. Read More
Myelin thickness and oligodendrocytes were significantly reduced in the prefrontal cortex in mouse models of Williams syndrome. Read More
The formation of prefrontal cortex dendritic spine formation sustains the remission of depressive related symptoms and behaviors following ketamine treatment by restoring lost spines. Read More
Increased kynurenic acid production has been implicated in the pathology of schizophrenia. The findings provide a new target for cell-specific treatments that help reduce the production of kynurenic acid and reduce symptoms of schizophrenia. Read More
Contrary to popular belief that brain changes begin to normalize immediately after ceasing alcohol consumption, a new study reveals damage to the brain continues during the first weeks of abstinence. Read More
Dopamine activation controls the ensemble activity of neurons and increases oscillatory activity in the prefrontal cortex. Read More
Increased levels of epoxide hydrolase in the prefrontal cortex were found in the brains of young mice whose mothers had suffered infection during pregnancy. Inhibiting epoxide hydrolase reverses cognitive and social deficits associated with neurodevelopmental disorders, such as ASD. Read More
