hospital for sick children

Researchers discovered key molecular mechanisms that shift children's memory formation from general or "gist-like" to event-based or "episodic". This change in memory formation typically occurs between ages four and six. The study identified that the maturation of inhibitory cells called parvalbumin-expressing (PV) interneurons, wrapped by a dense matrix called the perineuronal net, enables memory specificity and appropriately sized engrams.