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By: Neuroscience News
The enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord is responsible for initiating and maintaining neuropathic pain.
Targeting spinal Tiam1 with anti-sense oligonucleotides injected into the cerebrospinal fluid effectively alleviates pain hypersensitivity.
Neuropathic pain is often poorly managed and has a significant negative impact on quality of life.
The study highlights the importance of understanding the mechanisms underlying neuropathic pain in developing effective treatments.
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