Underlying Mechanism of Neuropathic Pain Revealed

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By: Neuroscience News

Findings

The enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord is responsible for initiating and maintaining neuropathic pain.

Findings

Targeting spinal Tiam1 with anti-sense oligonucleotides injected into the cerebrospinal fluid effectively alleviates pain hypersensitivity.

Findings

Neuropathic pain is often poorly managed and has a significant negative impact on quality of life.

Findings

The study highlights the importance of understanding the mechanisms underlying neuropathic pain in developing effective treatments.

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