Neuroscience research articles are provided.
What is neuroscience? Neuroscience is the scientific study of nervous systems. Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.
– These articles focus mainly on neurology research. – What is neurology? – Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. – Neurology research can include information involving brain research, neurological disorders, medicine, brain cancer, peripheral nervous systems, central nervous systems, nerve damage, brain tumors, seizures, neurosurgery, electrophysiology, BMI, brain injuries, paralysis and spinal cord treatments.
What is Psychology? Definition of Psychology: Psychology is the study of behavior in an individual, or group. Psychology news articles are listed below.
Artificial Intelligence articles involve programming, neural engineering, artificial neural networks, artificial life, a-life, floyds, boids, emergence, machine learning, neuralbots, neuralrobotics, computational neuroscience and more involving A.I. research.
Robotics articles will cover robotics research press releases. Robotics news from universities, labs, researchers, engineers, students, high schools, conventions, competitions and more are posted and welcome.
Genetics articles related to neuroscience research will be listed here.
Neurotechnology research articles deal with robotics, AI, deep learning, machine learning, Brain Computer Interfaces, neuroprosthetics, neural implants and more. Read the latest neurotech news articles below.
Researchers at the RIKEN Brain Science Institute in Japan have identified a key neuronal pathway that makes learning to avoid unpleasant situations possible. Published online in the November 20 issue of Neuron, the work shows that avoidance learning requires neural activity in the habenula representing changes in future expectations.
Learning to avoid threats is an essential survival skill for both humans and animals. To do so, animals must be able to predict a danger and then update their predictions based on their actions and new outcomes. Until now, the neural mechanisms underlying this process have been a mystery. However, in a series of ingenious experiments, a research team led by Hitoshi Okamoto of BSI have identified a brain area called the habenula as a region that makes avoidance-learning possible by outputting negative expectation signals to downstream serotonergic neurons in the brain-stem raphe nucleus.
To accomplish this, they first created a model system in which zebrafish learned to associate a red light with an electric shock in a test chamber, and then subsequently learned to escape the chamber before the shock occurred. They found that when fish saw the red light indicating a potential threat of shock, activity in habenular neurons increased, signifying their expectations of an unpleasant experience, and then decreased as fish learned to avoid the threat. This pattern exactly matches what is required for a brain region that represents changing aversive expectation value.
To investigate whether this information is necessary for avoidance learning, the team created several transgenic fish lines that allowed them to artificially activate or silence only habenular neurons that also project to serotonergic neurons of the raphe nucleus.
Using optogenetics, they showed that activating this pathway can mimic an adverse event and lead to avoidance learning. In one fish line, they inserted a gene encoding the light-activated ion channel Channelrhodopsin-2 into habenular neurons, which could then be activated when exposed to blue light via a fiber optic cable implanted in their brain. Remarkably, shining blue light onto these neurons each time fish swam to one side of the tank caused them to eventually avoid that side of the tank despite the absence of any real threat.
Next, to determine whether silencing the pathway prevents avoidance learning, they created another transgenic fish line in which habenula neurons could not communicate with the raphe. Not only did these fish fail to learn how to avoid places where they could be shocked, they seemed to persist in exhibiting a panic-like response to the red light.
The behaviors observed in this study are similar to what happens in human panic and anxiety disorders, in which the loss of appropriate expectation can lead to panic, or overly negative expectations (anxiety) can lead to avoidance of places or situations. Noting that patients with this disorder are often prescribed drugs that increase serotonin function, lead author Ryunosuke Amo speculates that, “their symptoms might be related to dysfunction of the habenulo-raphe pathway.”
Investigating evolutionally conserved behavior in vertebrates should lead to an understanding of neural mechanisms that regulate behavior. As Dr. Okamoto explains, “studying how the threat-expectation signals are transferred and utilized for behavioral learning could lead the way to better treatments for anxiety and panic disorders.”
[divider]About this optogenetics research[/divider]
Contact: Jens Wilkinson – RIKEN Source: RIKEN press release Image Source: The images are adapted from the RIKEN press release Original Research: Abstract for “The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger” by Ryunosuke Amo, Felipe Fredes, Masae Kinoshita, Ryo Aoki, Hidenori Aizawa, Masakazu Agetsuma, Tazu Aoki, Toshiyuki Shiraki, Hisaya Kakinuma, Masaru Matsuda, Masako Yamazaki, Mikako Takahoko, Takashi Tsuboi, Shin-ichi Higashijima, Nobuhiko Miyasaka, Tetsuya Koide, Yoichi Yabuki, Yoshihiro Yoshihara, Tomoki Fukai, and Hitoshi Okamoto in Neuron. Published online November 20 2014 doi:10.1016/j.neuron.2014.10.035
[divider]Share this Neuroscience News[/divider]