Scentful Slumbers: Enhancing Memory in Older Adults Through Nightly Aromatherapy

Summary: A new study demonstrates how nightly aromatherapy can enhance memory in older adults. Over six months, subjects were exposed to various natural oil fragrances for two hours each night, leading to a remarkable 226% increase in cognitive capacity.

This innovative approach leverages the known connection between olfaction and memory, offering a potential non-invasive strategy to combat cognitive decline and dementia.

Key Facts:

  1. Participants exposed to nightly aromatherapy showed a 226% increase in cognitive performance, as measured by a standard memory test.
  2. Neuroimaging revealed better integrity in the brain pathway known as the left uncinate fasciculus, which connects the memory center to the decision-making prefrontal cortex.
  3. The study confirms the direct link between the olfactory sense and the brain’s memory circuits, underscoring the potential of aromatherapy as a non-invasive memory enhancement technique.

Source: UC Irvine

When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed.

Participants in this study by University of California, Irvine neuroscientists reaped a 226% increase in cognitive capacity compared to the control group.

The researchers say the finding transforms the long-known tie between smell and memory into an easy, non-invasive technique for strengthening memory and potentially deterring dementia.

Credit: Neuroscience News

The team’s study appears in Frontiers in Neuroscience.

The project was conducted through the UCI Center for the Neurobiology of Learning & Memory. It involved men and women aged 60 to 85 without memory impairment. All were given a diffuser and seven cartridges, each containing a single and different natural oil.

People in the enriched group received full-strength cartridges. Control group participants were given the oils in tiny amounts. Participants put a different cartridge into their diffuser each evening prior to going to bed, and it activated for two hours as they slept.

People in the enriched group showed a 226% increase in cognitive performance compared to the control group, as measured by a word list test commonly used to evaluate memory. Imaging revealed better integrity in the brain pathway called the left uncinate fasciculus.

This pathway, which connects the medial temporal lobe to the decision-making prefrontal cortex, becomes less robust with age. Participants also reported sleeping more soundly.

Scientists have long known that the loss of olfactory capacity, or ability to smell, can predict development of nearly 70 neurological and psychiatric diseases. These include Alzheimer’s and other dementias, Parkinson’s, schizophrenia and alcoholism.

Evidence is emerging about a link between smell loss due to COVID and ensuing cognitive decrease. Researchers have previously found that exposing people with moderate dementia to up to 40 different odors twice a day over a period of time boosted their memories and language skills, eased depression and improved their olfactory capacities.

The UCI team decided to try turning this knowledge into an easy and non-invasive dementia-fighting tool.

“The reality is that over the age of 60, the olfactory sense and cognition starts to fall off a cliff,” said Michael Leon, professor of neurobiology & behavior and a CNLM fellow.

“But it’s not realistic to think people with cognitive impairment could open, sniff and close 80 odorant bottles daily. This would be difficult even for those without dementia.”

This shows an older woman surrounded by flowers.
The researchers say the results from their study bear out what scientists learned about the connection between smell and memory. Credit: Neuroscience News

The study’s first author, project scientist Cynthia Woo, said: “That’s why we reduced the number of scents to just seven, exposing participants to just one each time, rather than the multiple aromas used simultaneously in previous research projects.

“By making it possible for people to experience the odors while sleeping, we eliminated the need to set aside time for this during waking hours every day.”

The researchers say the results from their study bear out what scientists learned about the connection between smell and memory.

“The olfactory sense has the special privilege of being directly connected to the brain’s memory circuits,” said Michael Yassa, professor and James L. McGaugh Chair in the Neurobiology of Learning & Memory. The director of CNLM, he served as collaborating investigator.

“All the other senses are routed first through the thalamus. Everyone has experienced how powerful aromas are in evoking recollections, even from very long ago. However, unlike with vision changes that we treat with glasses and hearing aids for hearing impairment, there has been no intervention for the loss of smell.”

The team would next like to study the technique’s impact on people with diagnosed cognitive loss. The researchers also say they hope the finding will lead to more investigations into olfactory therapies for memory impairment.

A product based on their study and designed for people to use at home is expected to come onto the market this fall.

Funding: The study was supported by Procter & Gamble.

About this olfaction and memory research news

Author: Ethan Perez
Source: UC Irvine
Contact: Ethan Perez – UC Irvine
Image: The image is credited to Neuroscience News

Original Research: Open access.
Overnight olfactory enrichment using an odorant diffuser improves memory and modifies the uncinate fasciculus in older adults” by Michael Leon et al. Frontiers in Neuroscience


Overnight olfactory enrichment using an odorant diffuser improves memory and modifies the uncinate fasciculus in older adults

Objective: Cognitive loss in older adults is a growing issue in our society, and there is a need to develop inexpensive, simple, effective in-home treatments. This study was conducted to explore the use of olfactory enrichment at night to improve cognitive ability in healthy older adults.

Methods: Male and female older adults (N = 43), age 60–85, were enrolled in the study and randomly assigned to an Olfactory Enriched or Control group. Individuals in the enriched group were exposed to 7 different odorants a week, one per night, for 2 h, using an odorant diffuser. Individuals in the control group had the same experience with de minimis amounts of odorant. Neuropsychological assessments and fMRI scans were administered at the beginning of the study and after 6 months.

Results: A statistically significant 226% improvement was observed in the enriched group compared to the control group on the Rey Auditory Verbal Learning Test and improved functioning was observed in the left uncinate fasciculus, as assessed by mean diffusivity.

Conclusion: Minimal olfactory enrichment administered at night produces improvements in both cognitive and neural functioning. Thus, olfactory enrichment may provide an effective and low-effort pathway to improved brain health.

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