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Pain

Pain Neuroscience news articles cover science research about pain receptors, nociceptors, nociception, sensory neurons, somatosensory cortex, chronic pain, acute pain, nocioceptors, musculoskeletal pain, therapies, phantom limb pain and other pain research.

Featured Neurology Neuroscience Pain

·October 10, 2019·6 min read

Brain mechanisms have potential to block arthritis pain

Researchers discover the amygdala is a critical site of action for pain modulation. An existing compound, LY379268, provides pain-relieving effects and helps to reduce anxiety.

Featured Neurology Neuroscience Pain

·January 13, 2025·3 min read

Brain Oscillations Decode Pain Intensity

Parvalbumin (PV) interneurons in the primary somatosensory cortex (S1) have been identified as key players in encoding pain intensity and driving gamma oscillations, according to a study. Cross-species experiments confirmed that gamma oscillations in S1 selectively reflect pain levels in humans and are linked to PV interneuron activity in rodents. Optogenetic manipulation of these interneurons demonstrated their ability to modulate pain-related behaviors, solidifying their role in pain processing.

Featured Neurology Neuroscience Pain

·May 26, 2026·8 min read

Brain Pathway Identified That Amplifies Nocebo Pain Responses

Summary: Researchers mapped the precise brain pathway that drives the nocebo effect, the biological phenomenon where negative expectations actively amplify...

Featured Neuroscience Pain Psychology

·July 10, 2025·6 min read

Brain Pathway Reveals How Pain Feels Emotionally

Pain is more than a physical signal — it also carries emotional weight that shapes our response and memory of discomfort. A new study identifies a group of neurons in the thalamus that directly links pain signals to the brain’s emotional center.

Featured Neurology Pain

·August 6, 2020·4 min read

Brain Waves Can Be Used to Predict Future Pain Sensitivity

Alpha wave frequency measurement can accurately predict how a person will experience pain.

Featured Neurology Neuroscience Pain

·July 13, 2024·5 min read

Brain’s Lymphatic System Plays Role in Migraine Pain

Researchers discovered how the protein CGRP affects the brain's lymphatic system, contributing to migraine pain. Their study reveals that CGRP prevents cerebrospinal fluid from draining, influencing migraine attacks. This finding could lead to new therapeutic strategies for migraines. More research is needed to understand the sex differences in migraine prevalence.

Featured Neurology Open Neuroscience Articles Pain

·February 13, 2019·7 min read

Breakthrough in Developing Blood Test for Pain

Researchers have identified biomarkers in the blood which can help determine the severity of a person's pain level. The findings could help doctors to accurately measure pain and stem the opioid crisis.

Featured Neurology Neuroscience Open Neuroscience Articles Pain

·July 15, 2022·8 min read

Building a Better Painkiller

Cannabidiol (CBD) simultaneously acts on two targets in pain-sensing neurons. Researchers are developing new drugs that have similar actions to CBD that may be better absorbed by the body.

Featured Neurology Pain

·May 8, 2017·6 min read

Caffeine and More Sleep Help Improve Chronic Pain

Researchers report getting more sleep, and for those who can't sleep, increasing caffeine uptake, can help relieve chronic pain better than standard pain killers.

Featured Neurology Neuroscience Pain

·January 30, 2023·5 min read

Calcium Channels Regulate Neuroinflammation and Neuropathic Pain

The Orai1 class of calcium channels regulates sex differences in the functioning of immune cells associated with neuroinflammation and neuropathic pain.

Featured Neurology Neuroscience Pain

·December 20, 2021·7 min read

Can a Dangerous Microbe Offer a New Way to Silence Pain?

A specific anthrax toxin blocks multiple types of pain in mouse models, a new study reports.

This shows a man holding his head in pain

Featured Neurology Neuroscience Pain

·March 1, 2021·2 min read

Can Cannabis Use Lead to Rebound Headaches for People With Migraine?

People who use cannabis to help manage the pain associated with chronic migraine are six times more likely to suffer from rebound headaches, or medication overuse headaches, than those who do not use marijuana.

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Pain

Brain mechanisms have potential to block arthritis pain

Brain Oscillations Decode Pain Intensity

Brain Pathway Identified That Amplifies Nocebo Pain Responses

Brain Pathway Reveals How Pain Feels Emotionally

Brain Waves Can Be Used to Predict Future Pain Sensitivity

Brain’s Lymphatic System Plays Role in Migraine Pain

Breakthrough in Developing Blood Test for Pain

Building a Better Painkiller

Caffeine and More Sleep Help Improve Chronic Pain

Calcium Channels Regulate Neuroinflammation and Neuropathic Pain

Can a Dangerous Microbe Offer a New Way to Silence Pain?

Can Cannabis Use Lead to Rebound Headaches for People With Migraine?

Key Brain Circuit Linked to Teen Anxiety Identified

Early Blindness Tunes Pitch Perception

LSD Microdosing Enhances Sustained Attention in Women

Cannabis Destroys Sleep Quality

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