Oxidative damage to telomeres can trigger cellular senescence. The findings could lead to the development of new therapeutics for healthy aging and to combat cancers.
Mutations in the ASD/intellectual disability genes ADNP and POGZ result in abnormal activation and overexpression of immune response genes and genes for microglia. This results in abnormal brain synaptic function, characteristic of ASD and ID.
Researchers identified differences in isoforms that control Treg cells and how that affects the body's immune system response.
Paternal depression may contribute to adolescent depression and behavioral problems, regardless of whether or not the father and child are genetically related, researchers say.
Researchers say pharmacogenomics can assist providers in determining the best antidepressant treatments for patients with depression and avoid prescribing medications that could have adverse effects.
Researchers have developed a new experimental human cell line from retinal pigment epithelial cells, dubbed ABC cells, that can assist with the study of blinding eye diseases, including age-related macular degeneration.