Glioma brain tumors alter the function of astrocytes, possibly contributing to seizures many brain cancer patients experience. Astrocytes encasing gliomas exhibit different molecular signatures based on their proximity to the cancer cells. Those directly touching the cancer cells become elongated and swollen, mimicking the astrocyte's response to other epilepsy-related brain injuries.
Combining medications used to treat neurological disorders, such as epilepsy and migraines, with blood pressure medications reversed some aspects of breast cancer in mice at high risk of developing the disease due to the high-fat diets fed to their mothers during pregnancy.
A new nanocarrier meets the size and stability to effectively pass the BBB and deliver drugs to glioblastoma multiforme brain cancer.
Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma. This is the first study to link known cancer-related genes HACE1 and LIN28B to neuroblastoma. The study broadens understanding of how gene changes may make a child susceptible to this early childhood cancer, as well as causing a tumor to progress.
A new, freely available computer platform creates a 3D model that brings together the macroscopic scale of tissue with the microscopic scale of individual cells. This allows the platform to realistically model brain cancer's mechanobiology while maintaining resolution power.
Researchers announce the discovery of a chemical probe, UNC1215, which could be used to investigate the function of malignant brain tumor domain proteins.
Night-shifts destroy the natural 24-hour biological rhythm in the activity of certain cancer-related genes, resulting in more vulnerability to DNA damage and causing a mistiming in the DNA repair mechanisms in shift workers.
Scientists have long believed that glioblastoma multiforme, the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. Researchers found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.