Tau-tangles trigger the inflammatory activation of microglia via the NF-κB pathway. Inhibiting the microglia NF-κB signaling pulled the immune cells out of their inflammatory state and reversed learning and memory problems in tau-based Alzheimer's mouse models.
A specific group of fungi in the intestines may protect against intestinal injury and influence social behaviors.
Ion channels use a "ball-and-chain" mechanism to help regulate ion flow. Findings confirm a long-standing hypothesis about ion channels and provide key advances in understanding the basic biological processes at work.
Mice bred to be germ-free, and those treated with antibiotics showed a significant reduction in the ability to learn that a threatening danger was no longer present. Sequencing the RNA of microglia in the brains of the animals reveals altered gene expression in the immune cells, which play a role in remodeling how neurons connect during the learning process. Restoring the gut microbiota reverse the learning problems.
A new study reports sensory stimulation during the first two weeks of life is critical for establishing brain networks that help map sensation.
Weill Cornell Medicine researchers may have answered why women are more likely to develop Alzheimer's disease than men. In a new PLOS ONE study, researchers reveal menopause can cause metabolic changes in the brain that appear to increase the risk of Alzheimer's disease.