The commercial dietary supplement nicotinamide riboside, touted to improve cardiovascular and neurological health, may actually increase the risk of developing breast cancer that metastasizes to the brain.
An association has been identified between a variant of the NAPRT1 gene, which reduces the body's ability to use Vitamin B3, and schizophrenia. The study reveals there could be a critical interaction between a pregnant woman's prenatal niacin deficiency due to malnutrition and the NAPRT1 variant, which impedes the fetus' ability to use niacin during development. The interaction between the gene and the prenatal environment may predispose the offspring to develop a psychiatric disorder.
NAPRT1, a gene that encodes an enzyme involved in vitamin B3 metabolism, may be a risk factor for schizophrenia. Knocking out the gene in zebrafish models, researchers discovered brain development became impaired. Without NAPRT1, the fish brains failed to divide symmetrically, which is significant as defects in the corpus callosum have been identified in those with schizophrenia.
Researchers report a form of vitamin B3 can help prevent neurological damage and improve cognition in mouse models of Alzheimer's disease.
Dietary Niacin can help boost levels of a compound associated with DNA repair, a new study reports.