Researchers report a gut-brain neural circuit establishes the vagus nerve as an essential component of the brain system that regulates reward and motivation.
Researchers report the administration of Lactobacillus reuteri may lead to brain changes that reverse social deficits in mouse models of ASD through a mechanism that involves the vagus nerve and reward system. The findings hold promise for the development of treatments for ASD, as well as other disorders, by modulating specific gut microbes.
Hydration signals from the gut travel via the vagus nerve to activate thirst neurons in the SFO. These neurons signal to cells in the median preoptic nucleus, driving animals to drink and the kidneys to conserve water in the bloodstream.
Non-invasive vagus nerve stimulation reduces inflammation and improves symptoms for those suffering from rheumatoid arthritis. The simulation technique helps inhibit the production of cytokines and reduces inflammatory response.
Inflammation of the colon is associated with alterations in alpha-synuclein expression and phosphorylation in the myenteric plexus of common marmoset monkeys. The findings support the growing body of evidence that inflammation may play a role in the development of Parkinson's disease.
A new study adds to the growing body of evidence that Parkinson's disease may start in the gut. Researchers found gut-to-brain propagation of alpha-synuclein spread via the vagus nerve. The study provides a more accurate model of Parkinson's progression and could lead to new treatments to halt or prevent this neurodegenerative disease.
Transcutaneous vagus nerve stimulation helps improve sleep patterns and mental health in aging people. The therapy works by increasing parasympathetic activity and decreasing sympathetic activity.
Lewy body disorders, including Parkinson's disease and Lewy body dementia, comprise of two distinct subtypes. One subtype originates in the peripheral nervous system (PNS) of the gut and spreads to the brain. The other originates in the brain, or enters the brain via the olfactory system, before spreading to the brainstem and PNS.
Non-invasive auricular transcutaneous vagus nerve stimulation (atVNS), applied to an accessible area of the ear, improves memory in mouse models of intellectual disability.