People with schizophrenia and other neuropsychiatric disorders may have a more permissive blood-brain barrier which allows the immune system to become more actively involved in the central nervous system. The resulting inflammation may contribute to the clinical manifestation of psychosis-like symptoms.
Researchers propose a new theory of what happens in the brain when we experience familiar seeming visual stimuli. The theory, dubbed sensory referenced suppression, suggests the brain understands different levels of activation expected for sensory input and corrects for it, leaving behind the signal for familiarity.
Combining neuroimaging data with artificial intelligence, researchers have identified two distinct neuroanatomical subtypes of schizophrenia. The first, more typical subtype is associated with a lower widespread volume of gray matter compared to healthy controls. In the second subtype, gray matter volume is largely similar to healthy brains.