A pathway linking the basal ganglia to the thalamus enhances sensory discrimination and is used to suppress 'background noise'. The pathway, which is controlled by the prefrontal cortex, selectively suppresses sensory input as it flows to the thalamus.
Mapping the thalamic reticular nucleus, researchers have identified two distinct subnetworks of neurons with different functions. Findings offer insight into more specific targets for therapeutics to alleviate some sensory, sleep, and attention symptoms associated with ASD and other disorders characterized by sensory hypersensitivity.
A new study identifies a neural pathway which controls attention.
Restoring normal sleep patterns by activating the thalamic reticular nucleus with chemogenetics reduced the accumulation of amyloid-beta plaques in the brains.
A new optogenetics study could be a breakthrough in understanding how the TRN influences consciousness.
Researchers have mapped the relationship of two types of neurons implicated in psychiatric and movement disorder. The findings could lead to new treatments for a range of disorders from depression to Parkinson's disease.