Researchers report activating microglia may help reduce the imbalance between neuroprotection and neurotoxicity for neurodegenerative diseases.
Findings point to microglial TREM2 as a potential target for the treatment of ALS.
Two rare genetic variants on the NOTCH3 and TREM2 genes have been identified in some Alzheimer's patients.
Stimulating activation of microglia may help eliminate Alzheimer's associated plaques, thus helping to prevent the progression of the neurodegenerative disease.
Researchers have identified 11 new genes which offer important new insights into the disease pathways associated with Alzheimer's disease.
A drug currently being tested in cancer clinical trials appears to prevent dysfunction in an immune cell signaling pathway associated with Alzheimer's disease. Blocking the pathway could prevent Alzheimer's from developing and slow the progression of symptoms for those who already have the disease.
Findings may help to shed light on how Alzheimer's and other neurodegenerative diseases develop.
Researchers report the TREM2 mutation can derail the immune cell's plaque-clearing activity.
Researchers from Cardiff University have identified two new genes that can influence a person's risk of developing Alzheimer's disease.
