FeaturedGeneticsNeurologyNeuroscience·September 30, 2024·5 min readGenetic Variants Linked to Alzheimer’s Trigger Inflammation in FemalesResearchers have discovered that two genetic variants, APOE4 and TREM2 R47H, together cause a harmful inflammatory response in brain immune cells, particularly in females. This response leads to more severe brain damage, including tau protein clumps, which are linked to Alzheimer’s disease progression.Read More
FeaturedNeurologyNeuroscience·June 7, 2022·3 min readRapamycin Increases Alzheimer’s-Associated Plaques in MiceRapamycin, a drug approved for the treatment of cancer and transplant patients increases amyloid-beta protein plaques in the brains of mice.Read More
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles·March 23, 2022·4 min readHow TREM2 Gene Mutation in Brain Microglia Immune Cells Can Increase Alzheimer’s RiskA molecular process caused by the TREM2 gene mutation in the brain's microglia increases the risk of Alzheimer's disease, a new study reports.Read More
FeaturedGeneticsNeurologyNeuroscience·February 14, 2022·3 min readHow a Gene Variant Protects Against Alzheimer’sThe P522R gene variant increases expression levels of several microglia genes which are reduced in people with Alzheimer's disease.Read More
FeaturedGeneticsNeurologyNeuroscience·January 9, 2022·3 min readResearch Clears up How Brain ‘Cleaners’ Fail in ALSFindings point to microglial TREM2 as a potential target for the treatment of ALS.Read More
FeaturedGeneticsNeurologyNeuroscience·December 1, 2021·4 min readTargeting the Brain’s Immune Cells May Help Prevent Alzheimer’s DiseaseA drug currently being tested in cancer clinical trials appears to prevent dysfunction in an immune cell signaling pathway associated with Alzheimer's disease. Blocking the pathway could prevent Alzheimer's from developing and slow the progression of symptoms for those who already have the disease.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·August 26, 2021·3 min readInflammatory Proteins Help Better Diagnose Progression of Alzheimer’s DiseaseTesting for specific inflammatory proteins in cerebrospinal fluid can help doctors to diagnose the early onset of Alzheimer's disease and track the progression of the disease in patients.Read More
FeaturedGeneticsNeurologyNeuroscience·March 9, 2021·6 min readCBD Reduces Plaque and Improves Cognition in Model of Familial Alzheimer’sA two-week course of CBD helps normalize and restore the function of two proteins associated with reducing amyloid-beta accumulation in mouse models of familial Alzheimer's disease. CBD also reduces levels of IL-6, an immune protein associated with inflammation in Alzheimer's patients.Read More
FeaturedGeneticsNeuroscienceOpen Neuroscience Articles·September 25, 2020·5 min readA Genetic Variant That Protects Against Alzheimer’s Promotes Immune Cell FunctionsPLCG2-P522R, a genetic variant that protects against Alzheimer's disease, enhances key functions of immune cells.Read More
FeaturedNeurologyOpen Neuroscience Articles·August 7, 2020·4 min readKey to Dialogue Between Brain Cells to Protect Against Stroke DiscoveredDHA treatment reduced the size of the damaged brain area and initiated a repair mechanism in animal models of stroke. DHA affected the levels of MANF and TREM2, two proteins critical for communication between brain cells.Read More
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles·March 10, 2020·4 min readStimulating immune cells to protect against Alzheimer’sStimulating activation of microglia may help eliminate Alzheimer's associated plaques, thus helping to prevent the progression of the neurodegenerative disease.Read More
FeaturedGeneticsNeurologyNeuroscience·July 11, 2019·4 min read‘Crosstalk’ between genes promotes brain inflammation in Alzheimer’sFindings could help in the development of treatments to prevent brain inflammation associated with Alzheimer's disease.Read More
