Tokyo University of Science

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Tokyo University of Science

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Featured Neuroscience Open Neuroscience Articles Psychology

·April 14, 2022·5 min read

A Drug That Cures Alcoholism May Be the Next Anti-anxiety Medication

Disulfiram, a drug commonly prescribed to treat chronic alcohol addiction, was shown to reduce anxiety levels in rodent models. The drug inhibits FROUNT protein and chemokine signaling pathways under its influence, suppressing overall glutamate transmission in the brain. This, in turn, helps reduce overall activity. The findings may signal a new way to treat anxiety in humans.

Featured Neurology Neuroscience Open Neuroscience Articles

·August 11, 2019·5 min read

High-energy lasers could be used to treat Alzheimer’s disease in the future

Far-infrared free-electron lasers may be a new way in which we fight the effects of Alzheimer's disease. Researchers report the technology can break down protein aggregates associated with the disease deep within the brain.

Autism Featured Genetics Neuroscience Psychology

·May 18, 2021·4 min read

Mutation Linked to Autism Impairs Oxytocin-Mediated Social Behavior

A genetic mutation of Caps2 impairs the release of oxytocin, leading to problems in regulating social behavior in those on the autism spectrum.

Featured Neuroscience Psychology

·June 28, 2021·4 min read

Novel Drug Reduces Anxiety-Like Behavior in Mice

KNT-127 reduced anxiety-like behaviors in mice, researchers report.

Featured Neurology

·July 20, 2020·4 min read

Oxytocin Could Be Used to Treat Cognitive Disorders Like Alzheimer’s

Oxytocin, the so-called "love hormone," could help to treat cognitive disorders, including Alzheimer's disease. Researchers demonstrated oxytocin reversed the effects of amyloid-beta on hippocampal LTP in mice. The findings suggest oxytocin could be used as a therapeutic for the treatment of Alzheimer's disease and other dementias.

Featured Neurology Neuroscience

·October 24, 2022·4 min read

Oxytocin Derivative Improves Cognitive Impairment in Alzheimer’s

An intranasally delivered oxytocin derivative helped improve cognitive function and reduced cognitive impairment in mouse models of Alzheimer's disease.

Featured Neuroscience Open Neuroscience Articles Psychology

·November 7, 2022·4 min read

Repeated Psychological Stress Is Linked With Irritable Bowel Syndrome-Like Symptoms

Chronic stress invokes irritable bowel syndrome-like symptoms in mouse models.

This shows a depressed looking woman sitting by a window

Featured Neuroscience Psychology

·September 22, 2021·3 min read

Second-Hand Psychological Stress Can Lead to Depression

Mouse study reveals chronic stress affects neurogenesis in the dentate gyrus.

Featured Neuroscience

·April 18, 2022·4 min read

Simple, Computationally-Light Model Can Simulate Complex Brain Cell Responses

The Izhikevich neuron model allows the simulation of both periodic and quasi-periodic responses in neurons at lower computational cost.

Featured Neurology Neuroscience

·February 22, 2021·4 min read

Target for Stroke Therapy in Blood-Brain Barrier Discovered

The stroke byproduct acrolein activates the precursor of heparanase, an enzyme that degrades the glycocalyx in the blood-brain barrier.

Featured Neuroscience Open Neuroscience Articles

·June 3, 2021·4 min read

The Dream Team: Drug Duo May Cure COVID-19

Two medications commonly used to treat inflammation and HIV infection have been repurposed in the fight against COVID-19. Researchers found combined cepharanthine/nelfinavir therapy can hasten the clearance of coronavirus infection from a person's lungs in as little as 4.9 days. Cepharanthine hindered the entry of SARS_CoV_2 into cells, preventing the virus from binding to a protein on the cell membrane it uses as a gateway. Nelfinavir prevented the virus from replicating inside cells by inhibiting a protein the virus relies on for replication.