Researchers discovered how the TGF-beta protein controls the process by which hair follicles, including stem cells, divide and form new cells or orchestrate apoptosis. The findings could provide new treatment options for baldness and therapies to speed up wound healing.
A synthesized small-molecule drug blocks the TGF-beta receptor in astrocytes and traverses the blood-brain barrier in mice. When administered, the drug lowered receptor activity to that seen in younger mice and reduced inflammation. The aged mice were able to navigate mazes and learn spatial tasks as well as younger mice.
According to researchers, the passage of molecules through astrocytes could play a critical role in disease and health.
A new study reports TGF-beta acts as a time signal which regulates neural stem cells' potential at different stages of brain development.
Researchers discover UPF1 helps determine whether an immature neural cell remains as a stem cell or develops into a functional neuron.