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TDP-43

Featured Neurology

·September 30, 2016·3 min read

Abnormal Brain Protein May Contribute to Development of Alzheimer’s

A new study reports on the role the protein TDP-43 plays in the development of Alzheimer's disease.

Featured Genetics Neurology Neuroscience

·March 16, 2023·5 min read

DNA Treatment Could Delay Paralysis That Strikes Nearly All Patients With ALS

DNA designer therapeutics restored levels of a protein critical to motor neuron function, restoring the activity that is impaired as a result of ALS.

Featured Genetics Neurology

·August 19, 2017·6 min read

Fundamental ALS Pathology Discovered

Researchers have identified a genetic mutation associated with both ALS and frontotemporal dementia.

Featured Neurology Open Neuroscience Articles

·June 3, 2014·3 min read

Molecular ‘Scaffold’ Could Hold Key to New Dementia Treatments

Researchers have discovered how a molecular scaffold, that allows key parts of cells to interact, comes apart in some neurodegenerative diseases.

Featured Genetics Neurology Neuroscience

·December 4, 2023·4 min read

The Role of Protein Misfolding in Neurodegenerative Diseases

Neurodegenerative diseases share a common factor: protein misfolding and deposits in the brain. Misfolded proteins can lead to toxic activity or the loss of the protein's physiological function, causing damage to neurons.

Image shows stained mouse brain slice. The caption provides more information.

Featured Neurology Neuroscience Videos

·September 30, 2015·3 min read

Dormant Viral Gene May Cause Some Forms of ALS

Researchers discover reactivating ancient viral genes may cause neuron destruction in some forms of ALS.

Featured Genetics Neurology Neuroscience

·May 26, 2026·10 min read

Gene Therapy Proven to Shield Brain from TDP-43 Damage

An experimental gene therapy called SynCav1 can protect the central nervous system from the cognitive decline linked to TDP-43-related proteinopathy, a primary driver of FTD, ALS, and over half of all Alzheimer’s cases.

This is a diagram of the brain and central nervous system.

Featured Neurology

·June 19, 2013·3 min read

Staging System in ALS Shows Potential Tracks of Disease Progression

Performing post-mortem staging of the brains and spinal cord tissue of patients with ALS, researchers discover the neurodegenerative disease could progress from one start point in the CNS to other regions of the brain and spinal cord.