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TDP-43

Featured Neurology Neuroscience

·July 9, 2026·10 min read

Loss of TDP-43 Strips Microglia of Their Brain-Cleaning Power

The TDP-43 protein is an essential regulator of microglial housekeeping in the developing brain.

Featured Neurology Neuroscience

·December 19, 2019·4 min read

Is there a link between lifetime lead exposure and dementia?

A new hypothesis suggests declining rates of dementia could be a result of generational differences in lifetime exposure to lead.

Featured Genetics Neurology

·January 15, 2019·5 min read

Potential Therapeutic Target for ALS Revealed

Researchers have identified the gene STMN2 as a novel biomarker and potential drug target for ALS.

Featured Neurology

·September 30, 2016·3 min read

Abnormal Brain Protein May Contribute to Development of Alzheimer’s

A new study reports on the role the protein TDP-43 plays in the development of Alzheimer's disease.

The image shows motor neurons in an ALS patient.

Featured Neurology

·December 16, 2013·5 min read

Researchers Reduce Toxicity Associated With Lou Gehrig’s Disease in Animal Models

Researchers discover a new way of reducing disease toxicity in ALS which slows the dysfunction of neurons.

Featured Neurology Open Neuroscience Articles

·May 30, 2017·5 min read

Motor Neuron Disease Discovery Offers New Insights into Potential Treatment Targets

A new study sheds light on how some forms of motor neuron disease begins and progresses at a cellular level.

Featured Genetics Neurology Neuroscience

·March 12, 2026·7 min read

Five High-Risk Neuron Groups Identified in ALS and FTD

New research reveals five specific types of neurons that are the primary targets of ALS and FTD, paving the way for cell-specific therapies.

Featured Neuroscience

·November 29, 2022·3 min read

Key Factors Identified for Regeneration of Brain Tissue

Researchers have identified two proteins that prevent the formation of scars in the brain and help promote the regeneration of new neural tissue.

Featured Neurology Neuroscience

·May 27, 2022·4 min read

On Your Back, Side, or Face-Down? How We Sleep May Trigger or Protect Our Brain From Diseases Like ALS

A new mouse study reveals our sleep position may influence the glymphatic system and could increase the risk of developing ALS or other neurodegenerative diseases.

This image shows neurons from a fruit fly and a person with ALS.

Featured Neurology

·January 23, 2015·3 min read

The Molecular Biology Behind ALS

Researchers report they have identified a molecular defect in motor neurons which could help explain the mechanisms underlying ALS.

Featured Genetics Neurology

·March 22, 2018·4 min read

Focusing on Early Stage of Illness May Be Key to Treating ALS

A new study reveals many inhibitory neurons are lost in early phases of ALS and FTD development. The findings show a contrast to other neurodegenerative diseases where excitatory neurons are lost early in the disorders.

Featured Genetics Neurology Neuroscience

·May 26, 2026·10 min read

Gene Therapy Proven to Shield Brain from TDP-43 Damage

An experimental gene therapy called SynCav1 can protect the central nervous system from the cognitive decline linked to TDP-43-related proteinopathy, a primary driver of FTD, ALS, and over half of all Alzheimer’s cases.