An over-production of eIF4E impairs microglial cells, hampering their ability to effectively prune synapses and leading to autism-like behaviors in male mouse models of ASD.
When T helper cells are absent in the brain, microglia remain suspended between the fetal and adult developmental state. Mice lacking brain T cells showed changes in behavior and defective synaptic pruning. The study reveals the critical role T cells play in the development of the brain.
Study reveals the specific changes that occur in the brains of mice exposed to cocaine. The findings shed new light on the role of dopamine in addiction, and provide new insight into dopamine transmission in the brain.