Researchers have directly observed excessive synaptic pruning in cells derived from people with schizophrenia.
Participating in exercise improved synaptic pruning in mouse models of autism. The study also found microglia dependant synaptic pruning is impaired by maternal inflammation, which has been previously connected to the development of ASD.
Emory researchers report a drug approved in Japan for stroke, can help to stimulate neural pruning and help reduce habit driven behaviors in mice.
A new study reports cannabis can prune synapses and destroy some neural circuits.
Study implicates C4, an immune system gene, in schizophrenia pathogenesis.
A new study reports a gene mutation linked to autism also plays a critical role when it comes to the formation and maturation of synapses.
Researchers discover proteins that play an important role in the immune system may be responsible for fine tuning motor control during development and reducing motor function as we age.
A new study reports pregnant women with high levels of inflammatory cytokines and chemokines may have a significantly increased risk of having a child with autism combined with an intellectual disability.
Researchers have identified a previously unknown stage of human brain development.
When T helper cells are absent in the brain, microglia remain suspended between the fetal and adult developmental state. Mice lacking brain T cells showed changes in behavior and defective synaptic pruning. The study reveals the critical role T cells play in the development of the brain.
Researchers report the frontoparietal network plays a key role in why humans have superior reasoning skills.
A gene associated with schizophrenia may trigger runaway synaptic pruning during adolescence, a new study reports.
