Neural networks play a key role in regulating circadian rhythms through the mediation of cAMP. The findings may help with developing new strategies to manage circadian rhythm problems such as sleep disorders.
Neurons in the suprachiasmatic nucleus coordinate to adapt to different lengths of daylight, changing at cellular and network levels. The neurons changed in mix and expression of dopamine, altering brain activity and subsequently daily routine behaviors.
Mouse study reveals the presence of the Baml1 gene in the striatum has a sexually dimorphic effect on alcohol consumption. Male mice without the protein consumed more alcohol than those who did, while the reverse was true for females.
During wakeful periods, the glymphatic system diverts cerebrospinal fluid to lymph nodes in the neck. The CSF may act as a "fluid clock" that helps initiate the body's infection-fighting capabilities during the day. Astrocytes in the suprachiasmatic nucleus may serve to control CSF through the central nervous system. Communication between astrocytes in different brain regions may optimize the glymphatic system's function as we sleep.