Premenstrual dysphoric disorder (PMDD) is a severe mood disorder that affects one in twenty women. PMDD can have a debilitating impact on the lives of sufferers. Researchers investigate PMDD and evaluate treatment options for sufferers.
The common antidepressant Prozac (fluoxetine) provokes an inflammatory response in the amniotic sac. The findings may reveal the underlying factor of why women who take SSRI antidepressants are at higher risk of preterm birth.
A newly identified serotonin pathway that originates from the median raphe nucleus acts in opposition to the reward/aversion pathway in the nearby dorsal raphe nucleus. The findings could pave the way for the development of new treatments for major depression, addiction, and other disorders associated with serotonin.
Taking SSRIs and having the "long-long" serotonin SERT genetic variant lowers SERT activity in the mitral valve, leading to degenerative mitral regurgitation, one of the most common heart valve diseases.
SSRI antidepressants can make users less sensitive to rewards, resulting in emotional blunting many users experience. The findings provide new evidence for the role serotonin plays in reinforcement learning.