Taking SSRIs and having the "long-long" serotonin SERT genetic variant lowers SERT activity in the mitral valve, leading to degenerative mitral regurgitation, one of the most common heart valve diseases.
Typically, many people associate depression with feelings of sadness or despair. However, depression can also affect your cognitive abilities and memory. A new paper reviews the impact depression has on cognitive function and considers therapy options to help improve these often overlooked symptoms of the disorder.
Researchers have identified a link between depression, antidepressant use and an increased risk of developing venous thromboembolism.
Using neuroimaging technology, researchers have identified three different subtypes of depressive disorder, including one that seems to be untreatable by common SSRI antidepressants.
Researchers shed new light on why some people may not respond to antidepressants for major depressive disorder. The study reports, neurons in the brains of some with MDD may become hyperactive in the presence of SSRIs.
Researchers explain how a molecular amplification system helps a new class of antidepressants alter brain signaling in specific neurons and how this produces the antidepressant effect.
Researchers have identified specific neurons in the hypothalamus that play a central role in triggering anxiety.
Retinal ganglion cell survival following a stroke depends on whether the pathway to the primary visual area remains active. Cells connected to inactive areas of the visual cortex suffer atrophy and degenerate, leading to permanent visual impairment.
Researchers report a single dose of a widely prescribed antidepressant causes quantifiable changes in the brain within a matter of hours.
SSRI antidepressants, such as Prozac and Paxil, interact with opioid medications to make them less effective at providing relief from chronic pain. Tramadol relies on activation of the CYP2D6 enzyme to control pain, but SSRIs inhibit this enzyme. Researchers suggest prescribing different classes of antidepressants which do not suppress the enzyme may benefit those in need of opioid medications. Alternatively, non-opioid pain killers should be considered for those who can not switch from SSRIs.
Antidepressant use has been linked to thicker arteries, possibly contributing to the risk of heart disease and stroke, in a...
Researchers found no association between in vitro exposure to SSRI antidepressants and an increased risk of a child developing depression.
