Severed axonal segments signal to Schwann cells to begin actin sphere formation and axon disintegration. If the process is disrupted, axon disintegration is slowed and axon fragments impair nerve regeneration.
A novel surgical technique that connects functioning nerves with injured nerves helps restore function to paralyzed muscles. Following surgery, 13 young adults with tetraplegia now have restored hand and elbow function, allowing them to feed themselves, hold a drink and write.
Axolotl salamander genes that allow the neural tube and nerve fibers to regenerate after spinal cord damage have been identified. These genes are also found in humans, but are activated differently.
Researchers have developed a novel 3D printed scaffolding that mimics natural anatomy and boost stem cell treatment for spinal cord repair. While the initial scaffolds have been designed for rat models of SCI, researchers report the approach is scalable to humans.
WUSTL researchers have developed a new, implantable and biodegradable device that delivers pulses of electrical activity to damaged peripheral nerves in rats, helping the animals to regrow nerves and improve nerve function.
Researchers say a novel enzyme treatment may reduce inflammation and scarring that prevents neural regeneration in spinal cord injury.
Researchers have successfully restored the ability to walk in mice paralyzed as a result of spinal cord injuries with the help of a small molecular compound.
Researchers have successfully used stem cell therapy to regenerate neurons in damaged areas of zebra fish spinal cords. The treatment helped to restore movement following SCI. The findings raise the possibility of developing new treatments for humans suffering paralysis as a result of spinal cord injury.
Researchers have successfully restored hand function and motor skills in rats who suffered paralysis as a result of spinal cord injury.