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SOD1

Image shows molecular structure of proteins.

Featured Genetics Neurology Neuroscience Videos

·December 31, 2015·5 min read

Study Opens New Doors for ALS Drug Discovery

Researchers pin down the structure of toxic clumps of a protein associated with a large number of ALS cases. The findings could help open the door to developing new drugs to treat the disease.

Featured Genetics Neurology Open Neuroscience Articles

·May 4, 2016·3 min read

Aggregated Protein in Neurons May Cause ALS

A new study reports people with ALs may have a genetic mutation that causes SOD1 to aggregate motor neurons in the brain and spinal cord.

Featured Neurology Open Neuroscience Articles

·May 16, 2016·3 min read

Second Gene Modifies Effect of Mutation in a Dog Model of ALS

Researchers have identified a modifier gene that affects the risk of developing degenerative myelopathy, a canine disease similar to ALS in Welsh corgis.

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·September 22, 2016·6 min read

Researchers Reverse Protein Clumping Involved in ALS

A new study reveals stabilizing the SOD1 protein can help reverse protein clumping in neurons affected by ALS.

Image shows an oligodendrocyte stained green.

Featured Neurology

·September 27, 2016·3 min read

Oligodendrocytes Induce Motor Neuron Death in ALS

A new study reports oligodendrocytes induce motor neuron death in ALS.

Image shows a schematic for MAM distribution in ALS.

Featured Genetics Neurology Open Neuroscience Articles

·November 8, 2016·3 min read

Collapse of Mitochondria-Associated Membrane in ALS

Researchers report a collapse of the mitochondria-associated membrane is a common halmark in two genetic forms of ALS.

Featured Genetics Neurology

·November 19, 2016·4 min read

Protective Molecule Sidelined in Models of ALS

Researchers have identified a naturally occurring molecule that has the potential for preserving sites of communication between nerves and muscles in ALS.

Image shows a diagram explaining how amitriptyline allows drugs to pass the bbb.

Featured Neurology Neuroscience

·April 27, 2017·4 min read

Antidepressants May Enhance Drug Delivery to Brain

A new study reports an antidepressant temporarily inhibits the blood-brain barrier, allowing drugs to enter the brain. The findings could have implications for treating neurological diseases from ALS to epilepsy.