A study suggests that spinal muscular atrophy (SMA), a genetic neuromuscular disease in infants and children, results primarily from motor circuit dysfunction, not motor neuron or muscle cell dysfunction, as is commonly thought. In a second study, the researchers identified the molecular pathway in SMA that leads to problems with motor function.
Researchers identify Neurexin2 as a new target for potential treatment of spinal muscular atrophy.
GABA plays a vital role in controlling the involuntary tics associated with Tourette Syndrome.
A new study reveals a link between brain activation, cardiorespiratory fitness and executive function in older adults.
A new study uncovers molecular changes which may explain why motor neurons, rather than other neurons, are affected by the childhood illness, SMA.
Researchers report insufficient blood supply could contribute to motor neuron loss in SMA.
A new study implicates a key cellular mechanism as defective in SMA for the first time, providing a new lead for developing future interventions.