Hematopoietic stem cell transplantation reversed neuromyelitis optica. Five years following transplantation, only 2 of twelve patients had relapsed.
Clotting proteins are elevated in the urine of patients with lupus nephritis. The findings provide a new biomarker for the autoimmune disease.
A key finding in the origins of lupus has been discovered. In those with systemic lupus erythematosus, B cells are abnormally activated. This results in the production of antibodies which react against the patient's own tissue, causing a range of symptoms including rashes, joint pain, and fatigue.
Rare gene variants BLK and BANK1 are present in a substantial percentage of people with Lupus. The genetic variants suppress 1RF5 and type-1 1Fn in B cells, causing dysfunction in the immune cells.
Skin cells may hold the key to explaining why women are more prone to developing autoimmune diseases, such as lupus than men. Researchers found women have more VGLL3 in their skin cells than men. VGLL3 pushes the immune system into overdrive, resulting in the 'self-attacking' autoimmune response, the mouse study revealed. Findings strongly implicate VGLL3 as a pivotal catalyst in sex-based autoimmunity.
Disruptions in maintaining X chromosome inactivation of T cells may explain why women are more prone to developing SLE than males.
Researchers report defects in the Ets1 gene is linked to characteristics associated with systemic lupus erythematosus immune abnormalities.
A study in Nature Immunology reports on the mechanism that helps to prevent autoimmune diseases from developing following infection. Researchers report a population of immune cells develop during late stages of the immune response to influenza infection.
According to researchers, rogue B cells can trigger an override that may be responsible for autoimmune attacks and diseases.
Researchers have identified 24 new genes associated with lupus.
A new study considers whether immune system changes in people with lupus contribute to neuropsychiatric symptoms associated with the disease.
Researchers have discovered a possible trigger for autoimmune diseases such as lupus, Crohn's disease and MS. Findings may explain how women are more susceptible to autoimmune disorders than men.
