Researchers report new findings about the immune system could help treat inflammation in Alzheimer's disease and could save people from deadly inflammation associated with sepsis.
Researchers have developed a novel antibody strategy to prevent the association between a harmless protein and a disease mediator that could lead to sepsis, and ultimately death. The findings could help to prevent sepsis induced by COVID-19 infections.
The activation of a neural circuit comprising of the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the first hours following sepsis infection induced anxiety behaviors in mice two weeks after the infection cleared. The behaviors mimicked the PTSD symptoms patients experience following sepsis infection.
Immunization with the vaccines for pneumococcal conjugate and rotavirus reduces the rates of acute respiratory infections and gastrointestinal infections in small children, thus reducing the need for antibiotic medications. Researchers say if universal childhood vaccination is achieved, an additional 40 million cases of antibiotic-treated illnesses could be prevented each year.
During sepsis, the body sheds fragments of heparan sulfate, which crossed the blood-brain barrier and enters the hippocampus. The presence of heparan sulfate in the hippocampus may cause memory loss associated with septic shock.