Researchers have identified a potential new drug target for COVID-19. The scientists mapped the anatomical structures of two critical SARS-CoV-2 proteins in the nsp10/nsp16 complex. If a drug can be developed to inhibit nsp10/nsp16, researchers believe the immune system should be able to detect the infection and eradicate it faster.
Stress, loneliness, and sleep loss can weaken the immune system, leaving people more susceptible to COVID-19. The best way to mitigate the negative health effects of stress and social isolation during the pandemic is to stay connected with others, particularly via video calls.
Researchers have launched a new interactive tool that compares hospital capacity with projected demand throughout the nation's 306 hospital regions. The app provides a clear picture of best and worst scenarios across each region for hospital capacity during the COVID-19 pandemic.
Researchers have decoded the 3-D architecture of the main SARS-CoV-2 protease. The protein is involved in the reproduction of the virus. The findings may help in the systematic development of drugs to inhibit the reproduction of the virus, potentially lowering COVID-19 infections.
Researchers report they have identified a vaccine candidate for COVID-19 and are working towards phase one clinical testing. A chimpanzee adenovirus vaccine vector was chosen as the most suitable vaccine technology for SARS-CoV-2 as it can generate a stronger immune response in one dose and is not a replicating virus.
As many as one in three COVID-19 patients report smell loss as an early symptom of the infection. Researchers say the loss of smell could be used as a key clinical indicator of infection in otherwise symptom-free or pre-symptomatic carriers of coronavirus.
VPM1002, a vaccine candidate based on the tuberculosis BCG vaccine, may be effective in protecting against COVID-19. Previous studies in mice have shown the BCG vaccine is effective at protecting against several respiratory viral infections. If effective against coronavirus, researchers hope the vaccine can bridge the time gap until a specific SARS-CoV-2 vaccine is available.
A new mathematical model shows the current COVID-19 pandemic could decline during the summer months, but return in the fall, with a major resurgence next winter. The model takes into account the seasonal variations of other closely related respiratory coronaviruses. Based on other coronavirus data, the model reveals infections were ten times more common between December and April in the northern hemisphere than between July and September. Researchers emphasize this model only attempts to examine possible scenarios, as we are currently unsure how warmer temperatures will affect SARS-CoV-2.
Community actions taken to slow the spread of COVID-19 may help to contain the virus and stop the exponential growth of cases. Researchers say the viral spread in China occurred in a fractal pattern. When social distancing was implemented, viral spread slowed. With more communities adopting social distancing measures, the spread became smaller in each new area exposed.
Researchers confirm ACE inhibitors and ARBS medications may increase the risk of patients with COVID-19 developing more severe symptoms.
Georgia Tech researchers are using 3D printing, plastic-lined table cloths, and an array of other items to craft personal protective equipment that can be used by healthcare workers treating COVID-19 patients. The team will share the designs for free, allowing for crowdsourcing of DIY protective gear.
Singapore model indicates quarantining people infected with COVID-19 and their family members, closing schools, and distancing, in that order, are effective at reducing transmission of the virus.