Specific transfer RNAs (tRNAs) are associated with epilepsy. The levels of tRNA fragments in blood samples are higher pre-seizure. The findings provide a novel biomarker for the detection of seizures prior to their occurrence.
Findings from a small sample study link small intestinal bacterial overgrowth (SIBO) to restless leg syndrome.
Studying brain tissue samples from people with ASD revealed a common set of alterations in genes associated with synaptic communication between neurons. The changes were identified mainly in neurons in the uppermost layers of the neocortex.
Genetic mutations which lead to abnormal RNA in regions of repeat DNA sequences set off anti-viral like inflammatory responses. This leads to apoptosis and ultimately trigger the onset of neurodegenerative diseases.
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Axon myelination is significantly disrupted in patients with Alzheimer's disease. Researchers also found brain cells of men and women vary significantly in how their genes respond to the neurodegenerative disease.
Researchers discovered changes in thousands of genes induced by the tumor microenvironment. The study may help in identifying new biomarkers for the early detection, and subsequent treatment, of brain cancers.
Researchers have created an organoid of the thalamus, which they have fused with an organoid of the frontal cortex in order to study ASD, depression and other neuropsychiatric conditions.