Flies without the Rim gene or cac Cav2 channel function displayed numerous cognitive and behavioral deficits associated with schizophrenia, and had reductions in synaptic growth and neural calcium transients. Exposing the flies with Rim deficits to the common antipsychotic haloperidol reduced some of the schizophrenia-related behavioral symptoms.
Researchers have identified the molecular machinery responsible for the release of dopamine. The findings could help develop new treatments for disorders such as Parkinson's disease and addiction.
Researchers provide new insight into the mechanisms of neurotransmission.
Researchers use a new technique to image the process of neurotransmission.
Researchers offer an explanation of how a single stimulus can sometimes trigger a different response, even in the same individual.