Researchers discover an abnormal protein that accumulates in the brains of patients affected with ALS and frontotemporal dementia. The findings have uncovered a potentially new therapeutic target and biomarker that would allow clinicians to confirm diagnosis of the diseases.
By simulating patterns of microvasculature cell growth and compare the results with real networks grown in lab, researchers hope to direct how they grow into the tiny blood vessels that feed the brain and help people regain functions lost to stroke and disease.
A nationwide clinical trial for a new type treatment that could offer help to those suffering from Duchenne Muscular Dystrophy, a devastating neuromuscular disease.
Researchers suggest the overexpression of a protein called alpha-synuclein appears to disrupt vital recycling processes in neurons. The study may have major implications for more fully understanding the causes and mechanisms of Parkinson’s disease.
Researchers identify a protein trafficking defect within brain cells that may underlie common non-familial forms of Parkinson’s disease. The study implicates two genetic variants that disrupt protein sorting in neurons.
While evidence suggests pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals, new research shows no evidence to support concerns that these abnormal disease proteins are “infectious” or transmitted from animals to humans or from one person to another.
Researchers have discovered that amyloid peptides are harmful to the blood vessels that supply the brain with blood in Alzheimer's disease, thus accelerating cognitive decline by limiting oxygen-rich blood and nutrients.
A training regimen to adjust the body's motor reflexes may help improve mobility for some people with incomplete spinal cord injuries. During training, the participants were instructed to suppress a knee jerk-like reflex elicited by a small shock to the leg. Those able to calm hyperactive reflexes saw improvements in their walking.
A comprehensive analysis of feeding behavior in children with autism spectrum disorders indicates that these children are five times more likely to have a feeding problem, including extreme tantrums during meals, severe food selectivity and ritualistic mealtime behaviors.
When the brain produces too much nitric oxide, it contributes to the severity and progression of stroke and neurodegenerative diseases such as Alzheimer’s. Researchers recently discovered that nitric oxide not only damages neurons, it also shuts down the brain’s repair mechanisms.
Researchers report that the protein Klotho plays an important role in the health of myelin, the insulating material allowing for the rapid communication between nerve cells. These findings may lead to new therapies for multiple sclerosis (MS) and Alzheimer's disease (AD).
Doctors implant left ventricular assist device (LVAD) to help stop the progression of heart disease and improve the quality of life in brothers with Becker's Muscular Dystrophy.