Calcium activity mediated by Piezo1 channels regulates the pathfinding of blood vessels in the developing brain.
Researchers have discovered a new mechanism which helps to control brain development.
Scientists have identified two proteins which may have a critical function in biological systems. The proteins, named Piezo1 and Piezo2, have been identified as being involved in cellular response to mechanical stimulation.
Study identifies a specific protein in sensory neurons that detects mechanical itch stimuli such as an insect crawling on the skin or when one touches an object that irritates the skin.
Removing Piezo1 from the surface of aged brain stem cells caused the cells to become rejuvenated and regain their normal regenerative function.
Piezo1 limits the potential of regulatory T cells (Treg) to mitigate autoimmune neuroinflammation. Inhibiting Piezo1 could lead to new treatments for autoimmune disorders like multiple sclerosis.
