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Picower Institute for Learning and Memory

Featured Genetics Neuroscience Open Neuroscience Articles

·December 8, 2020·6 min read

‘SCOUT’ Helps Researchers Find, Quantify Significant Differences Among Organoids

SCOUT is a newly developed pipeline for clearing, labeling, 3D imaging, and analyzing cerebral organoids.

This shows synapses and neurons imaged with the new method

Featured Neuroscience

·January 13, 2022·6 min read

Next-Generation Tissue Expansion Method Improves Neural Imaging

Researchers have developed a new method that vastly improves the imaging of the structures of neural connections using standard confocal microscopes.

Featured Neuroscience

·September 11, 2020·5 min read

As Information Flows Through Brain’s Heirarchy, Higher Regions Use Higher Frequency Waves

Study provides new insight into how brain waves control the flow of information through the cortex.

Featured Neuroscience Open Neuroscience Articles

·July 23, 2022·8 min read

How Neurons Build and Maintain Their Capacity to Communicate

Researchers reveal how neurons set up and sustain the vital infrastructure that allows for seamless neurotransmission.

This shows interneurons in the visual cortex

Featured Neuroscience Visual Neuroscience

·September 8, 2021·7 min read

Behind the Scenes, Brain Circuit Ensures Vision Remains Reliable

While some types of excitatory neurons respond to images and represent them in the visual cortex, the activity of two types of inhibitory interneurons combine in a circuit to reinforce visual stability and reliability.

Featured Neurology Neuroscience

·April 19, 2023·6 min read

Neurons Vulnerable to Alzheimer’s Identified

Researchers identified a subset of neurons in the mammillary body of the hypothalamus which are susceptible to hyperactivity and neurodegeneration. This damage often leads to memory impairment associated with Alzheimer's disease. Treating these neurons with a drug currently used in the treatment of epilepsy reverses memory impairments caused by this hyperactivity and neurodegeneration.

Featured Neuroscience

·April 27, 2022·6 min read

Anesthetic Drastically Diverts the Travels of Brain Waves

New findings reveal how anesthesia-induced unconsciousness differs from normal sleep in relation to delta wave activity in the brain.

Featured Neuroscience

·November 24, 2020·7 min read

Brain Waves Guide Us in Spotlighting Surprises

A dynamic interplay of different brainwave frequencies, not dedicated networks, governs how the brain acts to a novel surprise and downplays predictable stimuli.

Featured Neuroscience

·November 8, 2023·7 min read

How Anesthesia Blocks Consciousness

A new study reveals insights into how general anesthesia affects consciousness and sensory perception. Using animal models, researchers found that while propofol anesthesia allows sensory information to reach the brain, it disrupts the spread of signals across the cortex.

This shows a mouse brain and what looks like computer chips

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·February 23, 2021·6 min read

Basic Cell Health Systems Wear Down in Huntington’s Disease

Huntington's disease may progress to advanced stages as a result of degradation of the cells' health maintenance system than due to the increased disease pathology itself.

This shows a brain and a lightening bolt

Featured Neurology Neuroscience

·May 16, 2022·5 min read

Circuit Model May Explain How Deep Brain Stimulation Treats Parkinson’s Disease Symptoms

A new computer model shows the beneficial effects of deep brain stimulation arise from how it interrupts the cycle promoting runway beta in a circuit loop between the subthalamic nucleus and striatum.

Featured Neuroscience

·September 15, 2023·8 min read

Mice in Maze Shed New Light on Rodent Learning and Cognition

Researchers have delved deeper into mouse behavior, challenging previous assumptions about their cognitive strategies in reward-based learning tasks. While humans efficiently adopt the "win-stay, lose-shift" approach in "reversal learning" activities, mice were observed to blend this with an exploratory strategy.

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Picower Institute for Learning and Memory

‘SCOUT’ Helps Researchers Find, Quantify Significant Differences Among Organoids

Next-Generation Tissue Expansion Method Improves Neural Imaging

As Information Flows Through Brain’s Heirarchy, Higher Regions Use Higher Frequency Waves

How Neurons Build and Maintain Their Capacity to Communicate

Behind the Scenes, Brain Circuit Ensures Vision Remains Reliable

Neurons Vulnerable to Alzheimer’s Identified

Anesthetic Drastically Diverts the Travels of Brain Waves

Brain Waves Guide Us in Spotlighting Surprises

How Anesthesia Blocks Consciousness

Basic Cell Health Systems Wear Down in Huntington’s Disease

Circuit Model May Explain How Deep Brain Stimulation Treats Parkinson’s Disease Symptoms

Mice in Maze Shed New Light on Rodent Learning and Cognition

Wasabi Compound Enhances Memory

Genes Associated with Earlier and Higher Reproduction Linked to Accelerated Aging

Novel Multiple Sclerosis Treatment Shows Promise

Brain’s Response to Crucial Language Hub Removal: New Insights

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