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pharmacology

·April 11, 2020·3 min read

COVID-19: Six drug candidates identified

Six potential drug candidates have been identified as candidates to treat COVID-19 infections. The drugs, which have previously been subjected to clinical trials for treating a range of conditions, from arthritis to cancer, target Mpro, the main SARS-CoV-2 enzyme.

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·April 8, 2020·1 min read

Potential harms of chloroquine, hydroxychloroquine and azithromycin for treating COVID-19

Study warns of the potentially serious adverse effects of prescribing hydroxychloroquine and azithromycin for the treatment of COVID-19. Some of the potential side effects include cardiac arrhythmias, hypoglycemia, and neuropsychiatric effects.

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·April 2, 2020·4 min read

Trial drug may block early stages of COVID-19, human cell study shows

hrsACE2, a genetically modified protein already being tested to prevent lung disease, reduces the viral growth of SARS-CoV-2 by a factor of 1,000 to 5,000 in human cell cultures. Researchers believe the enzyme copy lures the virus to attach itself to the copy, rather than human lung cells. The findings suggest hrsACE2 could significantly block the early stages of SARS-CoV-2 infections and prevent COVID-19 from becoming severe.

This shows a pill with COVID-19 written on it

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·March 30, 2020·4 min read

Study identifies which medications are safe to use in COVID-19 treatment

Researchers found no evidence NSAIDs, such as ibuprofen, may result in worse outcomes for some COVID-19 patients or help control the virus. TNF blockers and JAK inhibitors, used to treat inflammation and arthritis, were also found to be safe to use. However, low amounts of prednisolone or tacrolimus therapy may be useful in treating coronavirus infection.

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·February 20, 2020·7 min read

Artificial intelligence yields drug that halts antibiotic-resistant bacteria

A new deep learning algorithm helped researchers identify a powerful new antibiotic compound that kills many of the world's most problematic, disease-causing bacterias, including those which have so far been resistant to common antibiotics.

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·January 13, 2020·3 min read

A replacement for exercise?

Sestrin, a naturally occurring compound, mimics many of the effects of exercise in mouse and fly models. The findings could help with the development of medications to help combat muscle wasting associated with aging and neurodegenerative diseases.

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·May 14, 2019·4 min read

Common antibiotic may increase nerve damage and peripheral neuropathy risk

Fluoroquinolone antibiotics, such as Levofloxacin and Ciprofloxacin, appear to increase the risk of peripheral neuropathy by 47%. However, there is no significant increased risk of developing neuropathy associated with amoxicillin use.

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·May 1, 2019·3 min read

Traces of Ketamine, Cocaine, Pharmaceuticals and Pesticides Found in Freshwater Shrimp

Researchers have found a diverse array of illicit drugs, including cocaine and ketamine, along with pesticides and pharmaceutical chemicals in British freshwater shrimp. While the concentrations of chemicals were considered low, researchers state there is a concern for the potential environmental risk this may pose to wildlife.

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·April 18, 2019·4 min read

Blood pressure drug shows promise for treating Parkinson’s and dementia in animal study

Felodipine, a common hypertension medication, induces autophagy and clears aggregate-prone proteins associated with neurodegenerative diseases. The study reveals the drug clears mutant alpha-synuclein in the brains of mice at plasma concentrations to those seen in humans taking the medication. Felodipine appears to have some neuroprotective properties in mouse models of neurodegenerative diseases.

This shows a brain with the chemical structure of cbd

Featured Neuroscience

·April 17, 2019·2 min read

Cannabidiol could help deliver medications to the brain

Cannabidiol may be able to bypass the blood-brain barrier to effectively deliver medications directly to the brain.

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·April 11, 2019·3 min read

Ketamine reverses neural changes underlying depression-related behaviors: Mouse study

The formation of prefrontal cortex dendritic spine formation sustains the remission of depressive related symptoms and behaviors following ketamine treatment by restoring lost spines.

This shows a woman listening to music on headphones

Featured Neurology Neuroscience Open Neuroscience Articles Pain

·March 31, 2019·5 min read

Pairing music with medication offers potential therapeutic strategy to manage pain

Classical music exposure paired with ibuprofen reduced response to inflammation pain by 93%, compared to exposure to the medication alone in mouse models of pain. For those exposed to just music, researchers report a 77% reduction in surgical pain.

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pharmacology

COVID-19: Six drug candidates identified

Potential harms of chloroquine, hydroxychloroquine and azithromycin for treating COVID-19

Trial drug may block early stages of COVID-19, human cell study shows

Study identifies which medications are safe to use in COVID-19 treatment

Artificial intelligence yields drug that halts antibiotic-resistant bacteria

A replacement for exercise?

Common antibiotic may increase nerve damage and peripheral neuropathy risk

Traces of Ketamine, Cocaine, Pharmaceuticals and Pesticides Found in Freshwater Shrimp

Blood pressure drug shows promise for treating Parkinson’s and dementia in animal study

Cannabidiol could help deliver medications to the brain

Ketamine reverses neural changes underlying depression-related behaviors: Mouse study

Pairing music with medication offers potential therapeutic strategy to manage pain

Hearing Aids Linked to 23% Lower Dementia Risk in Epilepsy

Reading Is the Ultimate Cognitive Enhancer

Dual Brain-Machine Interfaces Unlock Bionic Hand Kinesthesia

Overcoming Endothelial Sorting to Cure Glioblastoma

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