Reconstituting the amount of chondroitin 6-sulphate to perineuronal nets completely restored memory and brain plasticity in aging mice to a similar level as seen in younger animals, a new study reports. The findings could lead to new therapies to restore age-related memory loss in older humans.
Perineuronal nets (PNNs) and the neurons they enmesh can be damaged by poor diets. Excessive consumption of foods high in saturated fats and refined sugars cause inflammation and oxidative stress, resulting in cognitive decline and poor memory.
Altering the structure of perineuronal nets could be a mechanism that underlies sleep-induced memory changes.
Researchers identify a new mechanism that contributes to learning an association between a warning noise and a fearful event.
Researchers report vitamin D levels affect perineuronal nets in the hippocampus. The study found vitamin D deficiency resulted in a significant decline in memory and learning in mouse models.
Ketamine and exposure to 60-hertz flickering light show promise as a potentially new, non-invasive therapy to help rejuvenate the aging brain.
Researchers have solves a longstanding mystery relating to perineuronal nets, giving rise to potential new treatments for epilepsy. The study reports the nets modulate electrical impulses in the brain and seizures can occur if perineuronal networks are dissolved.
Researchers demonstrate how a single injection of fibroblast growth factor 1 (FGF1) can restore blood sugar levels to normal for extended periods in rodent models of type 2 diabetes. Studies show how FGF1 affects specific neurons and perineuronal nets to help restore blood sugar levels to normal, thus sending diabetes into remission.