Researchers report activating the SIRT1 gene in male mice helped to reverse symptoms of depression, such as social isolation and loss of interest. The study suggests drugs that activate SIRT1 may be an effective therapy for some with major depression.
A new study reveals mindfulness can act as a buffer against the pain and distress of social rejection.
Neuroimaging study reveals teens with more gray matter in the caudate nucleus and left cerebellum were at increased risk of problem alcohol use over time. The findings reinforce the idea that brain structure differences may contribute to both psychiatric and substance use disorders.
Anticholinergic drugs, commonly prescribed to treat a range of disorders, from Parkinson's disease to bladder conditions, may increase dementia risks. The increased risk was linked to anticholinergic antidepressants, antipsychotics, bladder control, epilepsy and Parkinson's disease medications. There were no increased risks associated with other types of anticholinergics, such as gastrointestinal drugs or antihistamines.
For some, insomnia may be caused by failing to neutralize emotional distress. Researchers speculate the sleep disorder could be caused by brain circuits that regulate emotion.
FIASMA antidepressants, such as amitriptyline and desipramine, halt the growth of four different kinds of bacterial pathogens in cell cultures and animal models. The antidepressants have shown to be effective in killing intracellular bacteria in two chlamydia infections, as well as human granulocytic anaplasmosis, a tick-borne disease that attacks white blood cells.
Recently, the WHO declared vaccine hesitancy one of the top ten international public health problems. They report the crisis is man-made, unnecessary and dangerous. Researchers are calling on search engines and social media organizations to do more to stem anti-vaccine rhetoric, and stop the spread of disinformation surrounding vaccinations. They also call for governments to better support mandatory immunization programs.
Researchers implanted a genetic mutation that encodes the DAT protein from a child with ASD into mice. The mice began to exhibit autism-like behavioral deficits. Mice with the DAT T356M mutation had reduced social interaction and a loss in social dominance. The mice also demonstrated an increase in hyperactivity. At the physiological level, the researchers found impaired striatal dopamine transmission and clearance.