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oligomers

·February 17, 2020·4 min read

Beta-arrestin-2 increases neurotoxic tau driving frontotemporal dementia

The protein beta-arrestin-2 increases tau tangle accumulation in Alzheimer's disease and frontotemporal dementia but interfering with the removal of excess tau from the brain.

Featured Genetics Neurology Neuroscience

·January 15, 2020·3 min read

Inflammation a “game changer” as cellular death dance discovered

TNFR1 receptors arrange themselves into clusters, joining together trimers and making oligomers that create a pro-inflammatory response observed in a variety of diseases.

Featured Neurology

·August 1, 2018·4 min read

Alzheimer’s Drug May Stop Disease If Used Before Symptoms Appear

Researchers report memantine, an FDA approved drug, may not only alleviate symptoms of mild Alzheimer's disease, but could also prevent progression of the disease if used before symptoms appear.

Featured Neurology Neuroscience Open Neuroscience Articles

·July 26, 2018·4 min read

Traffic Jams in the Brain

A new study reports disrupted transportation routes in nerve cells are a significant cause of Parkinson's disease.

Featured Neurology Open Neuroscience Articles

·June 28, 2018·3 min read

New Mechanism to Explain the Spread of Alzheimer’s Discovered

Researchers report exosomes help neuron-to-neuron growth and the transfer of oligomer amyloid beta, resulting in apoptosis. The study reveals exosomes may be a primary mediator of the pathogenic progression of Alzheimer's disease.

Featured Neurology

·April 9, 2018·3 min read

Overlapping Mechanisms in HIV Cognitive Disorders and Alzheimer’s

A new Journal of Neuroscience study reports elevated levels of BACE1, an enzyme associated with neuronal damage in Alzheimer's disease, were identified in postmortem brain samples of those with HIV.

Featured Neurology

·October 19, 2017·5 min read

Binding Sites on Amyloid Beta Peptide Discovered

Researchers have invented a probe that lights up when it binds to a misfolded amyloid peptide.

Featured Neurology

·October 11, 2017·4 min read

How Green Tea Extract Could Help Protect Against Alzheimer’s

Researchers reveal a compound in green tea extract may help protect the brain against cognitive decline associated with Alzheimer's by coating toxic oligomers.

Featured Neurology

·December 22, 2016·3 min read

Promising Discovery For A Non-Invasive Early Detection of Alzheimer’s

A new paper details a technology that can detect pathological oligomeric forms of tau in Alzheimer's patients through human blood platelets.

Featured Neurology

·November 23, 2016·3 min read

New Imaging Technique Measures Toxicity of Proteins Associated With Alzheimer’s and Parkinson’s Diseases

Researchers have developed a new imaging technique that makes it possible to study why proteins associated with Alzheimer’s and Parkinson’s diseases may go from harmless to toxic.

Image shows the location of the hypothalamus.

Featured Neurology Neuroscience Videos

·October 3, 2016·6 min read

Computer Simulations Explore How Alzheimer’s Starts

A new study reports a computer simulation has been able to explore the initial steps of the molecular processes that lead to Alzheimer's disease.

Featured Neurology

·June 10, 2016·4 min read

New Clues to Toxic Forms of Amyloid Beta in Alzheimer’s

Researchers made a subtle alteration to the amyloid beta protein. The change affect its aggregation behavior and stabilizes an intermediate form with enhanced toxicity.