NMDA

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NMDA

·July 10, 2019·3 min read

Brain on Fire: Puzzling brain disease could now be better diagnosed and treated

A rare autoimmune disorder popularized by the autobiography and movie "Brain on Fire" is triggered by an attack on NMDA receptors. The disease occurs when antibodies attack NMDA receptors in the brain, leading to memory loss, intellectual changes, seizures, and death.

Featured Neuroscience Psychology

·July 31, 2019·4 min read

Ketamine isn’t an opioid and treats depression in a unique way

A new study clarifies the mechanism behind how ketamine works as an antidepressant. Researchers say there is evidence to suggest ketamine binds to NMDA receptors, instead of opioid receptors. Reducing the belief that ketamine is an opioid may make patients with depression more open to using the treatment.

Featured Neurology Neuroscience

·August 16, 2019·4 min read

More Than Just Jaundice: Bilirubin May Protect The Brain

Bilirubin, a bile pigment most commonly associated with jaundice in newborns, appears to have neuroprotective properties. A new study in mice reveals bilirubin may protect the brain against oxidative stress.

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·November 26, 2019·5 min read

One shot of ketamine could reduce problem drinking

A single shot of ketamine administered to heavy drinkers following reactivation of their drinking memories led to a rapid decrease in the urge to drink. The effect lasted for over nine months.

This shows synaptic transmission in action

Featured Neuroscience Open Neuroscience Articles Psychology

·February 24, 2020·4 min read

Antibodies: The body’s own antidepressants

When autoantibodies are able to enter the bran and act on NMDA receptors, people experience relief from symptoms of anxiety, depression, and stress.

Featured Genetics Neuroscience Open Neuroscience Articles

·March 11, 2020·2 min read

JNK protein triggers neurons to withdraw their synapses when stressed

Using optogenetics to inhibit the JNK protein prevented synapses from shrinking in response to stress.

Featured Neuroscience Psychology

·June 5, 2020·3 min read

NMDA receptors may link psychosis and sleep deficits

NMDA receptor hypofunction is involved in the reduction of sleep spindles and delta oscillations, which appear in the brain during deep natural sleep. Findings confirm the role NMDA receptors play in sleep disorders that accompany psychotic states.

Featured Genetics Neurology Open Neuroscience Articles

·June 24, 2020·3 min read

Genetic malfunction of brain astrocytes triggers migraine

Familial hemiplegic migraine type 2 (FHM2) causes a malfunction of astrocytes in the cingulate cortex. Manipulating astrocytes in the cingulate cortex reversed the disfunction, preventing an increase in migraine-like symptoms in mice carrying the FHM2 defect.

Featured Neuroscience

·October 22, 2021·5 min read

VR Experiment With Rats Offers New Insights About How Neurons Enable Learning

Studying rats in a virtual reality maze, researchers discover certain hippocampal neurons play a vital role in a specific mechanism of navigation.

This shows the outline of a head made up of bubbles

Featured Neuroscience Open Neuroscience Articles Psychology

·April 16, 2022·6 min read

Modulating NMDA Receptor Activity Is the Key to Successful Treatment of PTSD

NYX-783, a newly discovered drug, helps modulate NMDA receptor function in neurons. The drug appears to be effective at suppressing the return of PTSD symptoms in rodent models.

Featured Neuroscience

·November 30, 2022·7 min read

Silent Synapses Are Abundant in the Adult Brain

The adult brain contains millions of "silent synapses", or immature connections between neurons that remain inactive until they are required for learning new information and storing new memories.

This shows a finger touching a drawing of a brain

Featured Neuroscience

·December 2, 2022·4 min read

How Ketamine Acts as a ‘Switch’ in the Brain

Ketamine alters neural activity in the cerebral cortex, silencing normally active neurons and activating neurons that are normally inactive. The ketamine activity-induced "switch" in brain regions associated with depression may help explain its treatment effects.

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