Researchers upend a long-held view about the basic functioning of a key receptor molecule involved in signaling between neurons. The study describes how a compound linked to Alzheimer's disease impacts NMDA receptors and weakens synaptic connections between brain cells.
In a promising finding for epileptic patients suffering from persistent seizures known as status epilepticus, researchers reported today that new medication could help halt these devastating seizures.
The findings in fruit fly larvae demonstrate the first known function for the sensory neurons and provide insights that could broaden the understanding of chronic pain syndromes in humans.
in a mouse model of Rett syndrome, researchers were able to reverse abnormalities in brain activity and improve neurological function by treating animals with an FDA-approved anesthesia drug, ketamine.
Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant like ketamine. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say NIH researchers.
CSHL structural biologists reveal molecular architecture of key NMDA receptor subunit Structure of GluN2D subunit when docked with certain neurotransmitters...